Combination of drug and stem cells neurotherapy: Potential interventions in neurotrauma and traumatic brain injury

NEUROPHARMACOLOGY

卷:145

Review

Zibara, Kazem^1,2  Ballout, Nissrine¹  Mondello, Stefania³  Karnib, Nabil⁴  Ramadan, Naify⁵  Omais, Saad⁶  Nabbouh, Ali⁴  Caliz, Daniela⁷  Clavijo, Angelica⁷  Hu, Zhen⁷  Ghanem, Noel⁶  Gajavelli, Shyam⁷  Kobeissy, Firas^4,8 

[1] Lebanese Univ, Lab Stem Cells, ER045, PRASE, Beirut, Lebanon

[2] Lebanese Univ, Biol Dept, Fac Sci 1, Beirut, Lebanon

[3] Univ Messina, Dept Biomed & Dent Sci & Morphofunct Imaging, Messina, Italy

[4] Amer Univ Beirut, Fac Med, Dept Biochem & Mol Genet, Beirut, Lebanon

[5] Karolinska Inst, Div Clin Pediat, Dept Womens & Childrens Hlth KBH, Stockholm, Sweden

[6] Amer Univ Beirut, Dept Biol, Beirut, Lebanon

[7] Univ Miami, Neurosurg, Lois Pope LIFE Ctr, Miami, FL 33136 USA

[8] Univ Florida, Program Neurotrauma Neuroprote & Biomarkers Res, Dept Emergency Med, Gainesville, FL 32611 USA

关键词: Neurotrauma;    Traumatic brain injury;    Cell therapy;    Stem cells;    Drug-based therapy;    Clinical trials;   

DOI  :  10.1016/j.neuropharm.2018.09.032

来源: Elsevier

【 摘 要 】

Traumatic brain injury (TBI) has been recognized as one of the major public health issues that leads to devastating neurological disability. As a consequence of primary and secondary injury phases, neuronal loss following brain trauma leads to pathophysiological alterations on the molecular and cellular levels that severely impact the neuropsycho-behavioral and motor outcomes. Thus, to mitigate the neuropathological sequelae post-TBI such as cerebral edema, inflammation and neural degeneration, several neurotherapeutic options have been investigated including drug intervention, stem cell use and combinational therapies. These treatments aim to ameliorate cellular degeneration, motor decline, cognitive and behavioral deficits. Recently, the use of neural stem cells (NSCs) coupled with selective drug therapy has emerged as an altemative treatment option for neural regeneration and behavioral rehabilitation post-neural injury. Given their neuroprotective abilities, NSC-based neurotherapy has been widely investigated and well-reported in numerous disease models, notably in trauma studies. In this review, we will elaborate on current updates in cell replacement therapy in the area of neurotrauma. In addition, we will discuss novel combination drug therapy treatments that have been investigated in conjunction with stem cells to overcome the limitations associated with stem cell transplantation. Understanding the regenerative capacities of stem cell and drug combination therapy will help improve functional recovery and brain repair post-TBI. This article is part of the Special Issue entitled Novel Treatments for Traumatic Brain Injury.

【 授权许可】

Free