Orexin/hypocretin is necessary for context-driven cocaine-seeking

NEUROPHARMACOLOGY

卷:58

Article; Proceedings Paper

Smith, Rachel J.¹  Tahsili-Fahadan, Pouya¹  Aston-Jones, Gary¹ 

[1] Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA

关键词: Self-administration;    Reinstatement;    Addiction;    Abstinence;    Orexin;    Cocaine;   

DOI  :  10.1016/j.neuropharm.2009.06.042

来源: Elsevier

【 摘 要 】

Orexin/hypocretin signaling at the orexin 1 receptor (OX1R) has recently been implicated in addiction and relapse. We examined the role of the orexin system in cocaine-seeking elicited by a drug-associated context following abstinence or extinction from chronic cocaine self-administration. Male Sprague-Dawley rats self-administered cocaine in 2-h sessions for 10 days, followed by extinction training or extended abstinence in the home cage. The OX1R antagonist SB-334867 (SB; 10, 20, or 30 mg/kg, i.p.) was administered prior to re-exposure to the cocaine self-administration environment. We found that pretreatment with SB significantly attenuated cocaine-seeking when rats were placed back into the self-administration environment following either 1 day or 2 weeks of abstinence (no extinction), or following extinction of cocaine-seeking in an alternative environment (distinct from the training environment). These results indicate that orexin signaling at OX1R is critical for conditioned cocaine-seeking elicited by a drug-associated context, following either extinction or abstinence. (C) 2009 Elsevier Ltd. All rights reserved.

【 授权许可】

Free