Effects of environmental enrichment on the incubation of cocaine craving

NEUROPHARMACOLOGY

卷:63

Article

Goldberg, Steven R.²  Solinas, Marcello¹ 

[1] Univ Poitiers, Neurobiol & Neuropharmacol Addict Grp, Expt & Clin Neurosci Lab, INSERM,U1084, F-86022 Poitiers, France

[2] NIDA, Preclin Pharmacol Sect, Behav Neurosci Res Branch, Intramural Res Program,NIH,Dept Hlth & Human Serv, Baltimore, MD 21224 USA

关键词: Addiction;    Treatment;    Relapse;    Neuroadaptation;    Stress;    Withdrawal;   

DOI  :  10.1016/j.neuropharm.2012.05.014

来源: Elsevier

【 摘 要 】

Recent studies have demonstrated that exposure to environmental enrichment (EE) during withdrawal periods reduces the risks of relapse to drug-seeking behavior. In this study, we investigated whether EE could prevent the development of time-dependent increases in cocaine-seeking behavior (incubation of craving). In addition, we investigated whether EE could eliminate already developed incubation and whether the effects of EE would last when enrichment is discontinued. For this, we allowed rats to self-administer cocaine for 10 daily 6 h sessions and measured cocaine-seeking 1,30 and 60 days after the last self-administration session. In between these tests, rats were kept in forced abstinence and housed either in EE or standard environments (SE). Between day 30 and 60 of withdrawal, half of the rats in each group were maintained in their original environmental condition and the other half was switched to the other environmental condition. We found that exposure to EE prevents development of incubation of cocaine craving and eliminates already developed incubation. In addition, contrary to our expectations, when EE was discontinued, its positive effects on incubation of craving disappeared. These results indicate that EE can reduce cocaine seeking but only temporarily and questions the hypothesis that EE can permanently eliminate the neural consequences of exposure to drugs of abuse. Therefore, stimulating environments could have positive effects on the treatment of cocaine addiction only if they are maintained for long periods of abstinence that encompass the time-frame during which addicts are most vulnerable to relapse. (C) 2012 Elsevier Ltd. All rights reserved.

【 授权许可】

Free