Adenosine and autism: A spectrum of opportunities

NEUROPHARMACOLOGY

卷:68

Review

Masino, Susan A.^1,2  Kawamura, Masahito, Jr.³  Cote, Jessica L.¹  Williams, Rebecca B.²  Ruskin, David N.^1,2 

[1] Trinity Coll, Neurosci Program, Life Sci Ctr, Hartford, CT 06106 USA

[2] Trinity Coll, Dept Psychol, Hartford, CT 06106 USA

[3] Jikei Univ, Sch Med, Dept Pharmacol, Minato Ku, Tokyo 1058461, Japan

关键词: Adenosine;    Anxiety;    Autism;    ATP;    Ketogenic diet;    Metabolism;   

DOI  :  10.1016/j.neuropharm.2012.08.013

来源: Elsevier

【 摘 要 】

In rodents, insufficient adenosine produces behavioral and physiological symptoms consistent with several comorbidities of autism. In rodents and humans, stimuli postulated to increase adenosine can ameliorate these comorbidities. Because adenosine is a broad homeostatic regulator of cell function and nervous system activity, increasing adenosine's influence might be a new therapeutic target for autism with multiple beneficial effects. This article is part of the Special Issue entitled 'Neurodevelopmental Disorders'. (c) 2012 Elsevier Ltd. All rights reserved.

【 授权许可】

Free