Transcript specificity in BDNF-regulated protein synthesis

NEUROPHARMACOLOGY

卷:76

Review

Ruiz, Claudia R.¹  Shi, Jay^1,2  Meffert, Mollie K.^1,2 

[1] Johns Hopkins Univ, Sch Med, Solomon H Snyder Dept Neurosci, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA

关键词: BDNF;    Synaptic plasticity;    Protein synthesis;    RNA-binding proteins;    microRNAs;    Post-transcriptional regulators;    Lin28;    Let-7;   

DOI  :  10.1016/j.neuropharm.2013.05.004

来源: Elsevier

【 摘 要 】

Brain-derived neurotrophic factor (BDNF) is a critical activity-dependent modulator of gene expression, which can regulate both transcription and translation. Several functions of BDNF, including the induction of dendrite outgrowth and long-term synaptic plasticity, are known to depend, in particular, upon the ability of BDNF to regulate protein synthesis. Although BDNF modestly increases total neuronal protein synthesis, substantial evidence indicates that BDNF induces the translation of only a small subset of expressed mRNAs and demonstrates an extraordinary degree of transcript specificity. The mechanism by which BDNF selectively upregulates the translation of only a discrete group of mRNAs is of intrinsic importance to its trophic function in promoting neuronal growth and plasticity, and is the focus of this review. (C) 2013 Elsevier Ltd. All rights reserved.

【 授权许可】

Free