Contributions of serotonin in addiction vulnerability

NEUROPHARMACOLOGY

卷:61

Review

Kirby, L. G.^1,2  Zeeb, F. D.³  Winstanley, C. A.³ 

[1] Temple Univ, Dept Anat & Cell Biol, Sch Med, Philadelphia, PA 19140 USA

[2] Temple Univ, Ctr Subst Abuse Res, Sch Med, Philadelphia, PA 19140 USA

[3] Univ British Columbia, Dept Psychol, Vancouver, BC V6T 1Z4, Canada

关键词: 5-hydroxytryptamine;    Impulsivity;    Relapse;    5-HT2 receptor;    Substance abuse;   

DOI  :  10.1016/j.neuropharm.2011.03.022

来源: Elsevier

【 摘 要 】

The serotonin (5-hydroxytryptamine; 5-HT) system has long been associated with mood and its dysregulation implicated in the pathophysiology of mood and anxiety disorders. While modulation of 5-HT neurotransmission by drugs of abuse is also recognized, its role in drug addiction and vulnerability to drug relapse is a more recent focus of investigation. First, we review preclinical data supporting the serotonergic raphe nuclei and their forebrain projections as targets of drugs of abuse, with emphasis on the effects of psychostimulants, opioids and ethanol. Next, we examine the role of 5-HT receptors in impulsivity, a core behavior that contributes to the vulnerability to addiction and relapse. Finally, we discuss evidence for serotonergic dysregulation in comorbid mood and addictive disorders and suggest novel serotonergic targets for the treatment of addiction and the prevention of drug relapse. This article is part of a Special Issue entitled 'Serotonin: The New Wave'. (C) 2011 Elsevier Ltd. All rights reserved.

【 授权许可】

Free