Emerging roles for the novel estrogen-sensing receptor GPER1 in the CNS

NEUROPHARMACOLOGY

卷:113

Review

Alexander, Amy^1,2  Irving, Andrew J.³  Harvey, Jenni^1,2 

[1] Univ Dundee, Ninewells Hosp, Div Neurosci, Dundee DD1 9SY, Scotland

[2] Univ Dundee, Sch Med, Dundee DD1 9SY, Scotland

[3] UCD, Conway Inst, Sch Biomol & Biomed Sci, Dublin D4, Ireland

关键词: G protein coupled estrogen receptor;    Hippocampal synaptic function;    Receptor trafficking;    Learning and memory;    Neuroprotection;    Synaptic plasticity;   

DOI  :  10.1016/j.neuropharm.2016.07.003

来源: Elsevier

【 摘 要 】

Estrogens play a key role in regulating reproductive and neuroendocrine function by activating classical nuclear steroid receptors that act as ligand gated transcription factors. However evidence is growing that estrogens also promote rapid non-genomic responses via activation of membrane-associated estrogen receptors. The G protein-coupled estrogen receptor (GPER1; also known as GPR30) has been identified as one of the main estrogen-sensitive receptors responsible for the rapid non-genomic actions of estrogen. In recent years, our understanding of the CNS actions of GPER1 s has significantly increased following the development of selective pharmacological tools and via the use of transgenic technologies to knockout GPER1 in mice. Here we review recent advances that have been made to uncover the role of GPER1s in the CNS. This article is part of the Special Issue entitled 'Lipid Sensing G Protein-Coupled Receptors in the CNS'. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free