Sex and the migraine brain

NEUROBIOLOGY OF DISEASE

卷:68

Review

Borsook, D.^1,2,7  Erpelding, N.^1,7  Lebel, A.^1,3,7  Linnman, C.^1,2,7  Veggeberg, R.^1,7  Grant, P. E.^4,7  Buettner, C.^5,6,7  Becerra, L.^1,2,7  Burstein, R.⁷ 

[1] Boston Childrens Hosp, PAIN Grp, Waltham, MA 02453 USA

[2] Boston Childrens Hosp, Massachusetts Gen Hosp, Waltham, MA 02453 USA

[3] Boston Childrens Hosp, Headache Clin, Waltham, MA 02453 USA

[4] Boston Childrens Hosp, Fetal Neonatal Neuroimaging & Dev Sci Ctr, Waltham, MA 02453 USA

[5] Beth Israel Deaconess Med Ctr, Div Gen Med & Primary Care, Boston, MA 02215 USA

[6] Beth Israel Deaconess Med Ctr, Dept Anesthesia & Crit Care, Boston, MA USA

[7] Harvard Univ, Sch Med, Cambridge, MA 02138 USA

关键词: Pain;    Women;    Puberty;    Hypothalamus;    Cortical spreading depression;    Headache;    Gonadotrophins;    Estrogen;    Progesterone;    Trigeminal;    Allostatic load;    Menstrual cycle;    Sleep;   

DOI  :  10.1016/j.nbd.2014.03.008

来源: Elsevier

【 摘 要 】

The brain responds differently to environmental and internal signals that relate to the stage of development of neural systems. While genetic and epigenetic factors contribute to a premorbid state, hormonal fluctuations in women may alter the set point of migraine. The cyclic surges of gonadal hormones may directly alter neuronal, glial and astrocyte function throughout the brain. Estrogen is mainly excitatory and progesterone inhibitory on brain neuronal systems. These changes contribute to the allostatic load of the migraine condition that most notably starts at puberty in girls. (C) 2014 Elsevier Inc. All rights reserved.

【 授权许可】

Free