NEUROBIOLOGY OF DISEASE | 卷:35 |
Chronic ketamine impairs fear conditioning and produces long-lasting reductions in auditory evoked potentials | |
Article | |
Amann, Laura C.1  Halene, Tobias B.1,2,3  Ehrlichman, Richard S.1  Luminais, Stephen N.1  Ma, Nan4  Abel, Ted4  Siegel, Steven J.1,3  | |
[1] Univ Penn, Dept Psychiat, SMRI Lab Expt Therapeut Psychiat, Philadelphia, PA 19104 USA | |
[2] Rhein Westfal TH Aachen, Dept Psychiat & Psychotherapy, Int Res Training Grp Schizophrenia & Autism 1328, Aachen, Germany | |
[3] Univ Penn, Transdisciplinary Tobacco Use Res Ctr, Philadelphia, PA 19104 USA | |
[4] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA | |
关键词: Ketamine; Event-related potential (ERP); Auditory evoked potential (AEP); Gating; Fear conditioning; Schizophrenia; Drug abuse; | |
DOI : 10.1016/j.nbd.2009.05.012 | |
来源: Elsevier | |
【 摘 要 】
Ketamine is an NMDA receptor antagonist with a variety of uses, ranging from recreational drug to pediatric anesthetic and chronic pain reliever. Despite its value in the clinical setting, little is known about the immediate and long-lasting effects of repeated ketamine treatment. We assessed the effects of chronic administration of a subanesthetic dose of ketamine on contextual fear conditioning, detection of pitch deviants and auditory gating. After four. but not two, weeks of daily ketamine injections, mice exhibited decreased freezing in the fear conditioning paradigm. Gating of the P80 component of auditory evoked potentials was also significantly altered by treatment condition, as ketamine caused a significant decrease in S1 amplitude. Additionally, P20 latency was significantly increased as a result of ketamine treatment. Though no interactions were found involving test week, stimulus and treatment condition, these results suggest that repeated ketamine administration impairs fear memory and has lasting effects on encoding of sensory stimuli. (C) 2009 Elsevier Inc. All rights reserved.
【 授权许可】
Free
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
10_1016_j_nbd_2009_05_012.pdf | 503KB | download |