Mitochondria and neuroprotection in stroke: Cationic arginine-rich peptides (CARPs) as a novel class of mitochondria-targeted neuroprotective therapeutics

NEUROBIOLOGY OF DISEASE

卷:121

Review

MacDougall, Gabriella^1,2,3,4  Anderton, Ryan S.^1,2,3,4  Mastaglia, Frank L.^1,2  Knuckey, Neville W.^1,2,5  Meloni, Bruno P.^1,2,5 

[1] Univ Western Australia, Ctr Neuromuscular & Neurol Disorders, Nedlands, WA, Australia

[2] Perron Inst Neurol & Translat Sci, Ground Floor,RR Block,8 Verdun St, Nedlands, WA 6009, Australia

[3] Univ Notre Dame Australia, Sch Heath Sci, Fremantle, WA, Australia

[4] Univ Notre Dame Australia, Inst Hlth Res, Fremantle, WA, Australia

[5] QEII Med Ctr, Sir Charles Gairdner Hosp, Dept Neurosurg, Nedlands, WA, Australia

关键词: Stroke;    Ischaemia;    Cationic arginine-rich peptides;    Mitochondria;    Mito-protection;    Oxidative stress;    Membrane potential;    Permeability transition;    Apoptosis;   

DOI  :  10.1016/j.nbd.2018.09.010

来源: Elsevier

【 摘 要 】

Stroke is the second leading cause of death globally and represents a major cause of devastating long-term disability. Despite sustained efforts to develop clinically effective neuroprotective therapies, presently there is no clinically available neuroprotective agent for stroke. As a central mediator of neurodamaging events in stroke, mitochondria are recognised as a critical neuroprotective target, and as such, provide a focus for developing mitochondrial-targeted therapeutics. In recent years, cationic arginine-rich peptides (CARPs) have been identified as a novel class of neuroprotective agent with several demonstrated mechanisms of action, including their ability to target mitochondria and exert positive effects on the organelle. This review provides an overview on neuronal mitochondria] dysfunction in ischaemic stroke pathophysiology and highlights the potential beneficial effects of CARPs on mitochondria in the ischaemic brain following stroke.

【 授权许可】

Free