Prefrontal cortical BDNF: A regulatory key in cocaine- and food-reinforced behaviors

NEUROBIOLOGY OF DISEASE

卷:91

Review

Pitts, Elizabeth G.¹  Taylor, Jane R.^2,3  Gourley, Shannon L.^4,5,6 

[1] Emory Univ, Yerkes Natl Primate Res Ctr, Grad Program Neurosci, Atlanta, GA 30322 USA

[2] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA

[3] Yale Univ, Dept Psychol, Interdept Neurosci Program, New Haven, CT USA

[4] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA USA

[5] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA

[6] Emory Univ, Grad Program Neurosci, Yerkes Natl Primate Res Ctr, Atlanta, GA 30322 USA

关键词: Instrumental;    Prelimbic;    Operant;    Orbitofrontal;    Addiction;    Review;    Goal-directed;   

DOI  :  10.1016/j.nbd.2016.02.021

来源: Elsevier

【 摘 要 】

Brain-derived neurotrophic factor (BDNF) affects synaptic plasticity and neural structure and plays key roles in learning and memory processes. Recent evidence also points to important, yet complex, roles for BDNF in rodent models of cocaine abuse and addiction. Here we examine the role of prefrontal cortical (PFC) BDNF in reward related decision making and behavioral sensitivity to, and responding for, cocaine. We focus on BDNF within the medial and orbital PFC, its regulation by cocaine during early postnatal development and in adulthood, and how BDNF in turn influences responding for drug reinforcement, including in reinstatement models. When relevant, we draw comparisons and contrasts with experiments using natural (food) reinforcers. We also summarize findings supporting, or refuting, the possibility that BDNF in the medial and orbital PFC regulate the development and maintenance of stimulus-response habits. Further investigation could assist in the development of novel treatment approaches for cocaine use disorders. (C) 2016 Elsevier Inc. All rights reserved.

【 授权许可】

Free