A model of symptomatic infantile spasms syndrome

NEUROBIOLOGY OF DISEASE

卷:37

Article

Scantlebury, Morris H.¹  Galanopoulou, Aristea S.²  Betancourth, David⁴  Moshe, Solomon L.^2,3 

[1] Albert Einstein Coll Med, Saul R Korey Dept Neurol, Lab Dev Neurol, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Dominick P Purpura Dept Neurosci, Bronx, NY 10461 USA

[3] Albert Einstein Coll Med, Dept Pediat, Bronx, NY 10461 USA

[4] CUNY Queens Coll, Dept Psychol, New York, NY USA

关键词: Infantile spasms;    West syndrome;    Autism;    Animal model;    Epilepsy;    Lipopolysaccharide;    Doxorubicin;    p-Chlorophenylalanine;    Neonatal rat;   

DOI  :  10.1016/j.nbd.2009.11.011

来源: Elsevier

【 摘 要 】

Infantile spasms are characterized by age-specific expression of epileptic spasms and hypsarrhythmia and often result in significant cognitive impairment. Other epilepsies or autism often ensue especially in symptomatic IS (SIS). Cortical or subcortical damage, including white matter, have been implicated in the pathogenesis of SIS. To generate a model of SIS, we recreated this pathology by injecting rats with lipopolysaccharide and doxorubicin intracerebrally at postnatal day (P) 3 and with p-chlorophenylalanine intraperitoneally at P5. Spasms occurred between P4 and 13 and were associated with ictal EEG correlates, interictal EEG abnormalities and neurodevelopmental decline. After P9 other seizures, deficits in learning and memory, and autistic-like behaviors (indifference to other rats, increased grooming) were observed. Adrenocorticotropic hormone (ACTH) did not affect spasms. Vigabatrin transiently suppressed spasms at P5. This new model of SIS will be useful to study the neurobiology and treatment of SIS, including those that are refractory to ACTH. (C) 2009 Elsevier Inc. All rights reserved.

【 授权许可】

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