Inflammation in ALS and SMA: Sorting out the good from the evil

NEUROBIOLOGY OF DISEASE

卷:37

Review

Papadimitriou, Dimitra^1,3  Le Verche, Virginia^1,3  Jacquier, Arnaud^1,3  Ikiz, Burcin^1,3  Przedborski, Serge^1,2,3  Re, Diane B.^1,3 

[1] Dept Neurol, New York, NY USA

[2] Dept Pathol & Cell Biol, New York, NY USA

[3] Ctr Motor Neuron Biol & Dis, New York, NY USA

关键词: Neuroinflammation;    Gliosis;    Astrocytosis;    Astrocytes;    Microgliosis;    Microglia;    Amyotrophic lateral sclerosis (ALS);    Superoxide dismutase 1 (SOD1);    Spinal muscular atrophy (SMA);   

DOI  :  10.1016/j.nbd.2009.10.005

来源: Elsevier

【 摘 要 】

Indices of neuroinflammation are found in a variety of diseases of the CNS including amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). Over the years, neuroinflammation, in degenerative disorders of the CNS. has evolved from being regarded as an innocent bystander accomplishing its housekeeping function secondary to neurodegeneration to being considered as a bona fide contributor to the disease process and, in some situations, as a putative initiator of the disease. Herein, we will review neuroinflammation in both ALS and SMA not only from the angle of neuropathology but also from the angle of its potential role in the pathogenesis and treatment of these two dreadful paralytic disorders. (C) 2009 Elsevier Inc. All rights reserved.

【 授权许可】

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