The blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates-Evidence from in vivo neuroimaging studies

NEUROBIOLOGY OF DISEASE

卷:35

Article

Astradsson, Arnar^1,2,5  Jenkins, Bruce G.^1,2,3  Choi, Ji-Kyung³  Hallett, Penelope J.^1,2,5  Levesque, Michele A.^1,2,5  McDowell, Jack S.^1,2,5  Brownell, Anna-Liisa^1,2,4  Spealman, Roger D.^1,2,5  Isacson, Ole^1,2,5 

[1] Harvard Univ, Belmont, MA 02478 USA

[2] McLean Hosp, NINDS Udall Parkinsons Dis Res Ctr Excellence, Belmont, MA 02178 USA

[3] Massachusetts Gen Hosp, Nucl Magnet Resonance Ctr, Athinoula A Martinos Ctr Biomed Imaging, Boston, MA 02114 USA

[4] Massachusetts Gen Hosp, MGH Positron Emiss Tomog Ctr, Boston, MA 02114 USA

[5] Harvard Univ, Sch Med, New England Primate Res Ctr, Southborough, MA 01772 USA

关键词: Levodopa;    Dyskinesia;    Primates;    Blood-brain barrier;    Imaging;    Gadolinium-DTPA;   

DOI  :  10.1016/j.nbd.2009.05.018

来源: Elsevier

【 摘 要 】

It has been suggested, based on rodent studies, that levodopa (L-dopa) induced dyskinesia is associated with a disrupted blood-brain barrier (BBB). We have investigated BBB integrity with in vivo neuroimaging techniques in six 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) lesioned primates exhibiting dopa-induced dyskinesia. Magnetic resonance imaging (MRI) performed before and after injection of Gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) revealed an intact BBB in the basal ganglia showing that L-dopa-induced dyskinesia is not associated with a disrupted BBB in this model. (C) 2009 Elsevier Inc. All rights reserved.

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