Neurogenetics of depression: A focus on reward processing and stress sensitivity

NEUROBIOLOGY OF DISEASE

卷:52

Review

Bogdan, Ryan^1,2  Nikolova, Yuliya S.²  Pizzagalli, Diego A.^3,4 

[1] Washington Univ, Dept Psychol, BRAIN Lab, St Louis, MO 63130 USA

[2] Duke Univ, Neurogenet Lab, Dept Psychol & Neurosci, Durham, NC 27708 USA

[3] Harvard Univ, McLean Hosp, Sch Med, Ctr Depress Anxiety & Stress Res, Belmont, MA 02478 USA

[4] Harvard Univ, McLean Hosp, Sch Med, McLean Imaging Ctr, Belmont, MA 02478 USA

关键词: Intermediate phenotype;    Depression;    Fmri;    Gene;    Dopamine;    Reward;    Stress;    CRH;    HPA axis;   

DOI  :  10.1016/j.nbd.2012.05.007

来源: Elsevier

【 摘 要 】

Major depressive disorder (MDD) is etiologically complex and has a heterogeneous presentation. This heterogeneity hinders the ability of molecular genetic research to reliably detect the small effects conferred by common genetic variation. As a result, significant research efforts have been directed at investigating more homogenous intermediate phenotypes believed to be more proximal to gene function and lie between genes and/or environmental effects and disease processes. In the current review we survey and integrate research on two promising intermediate phenotypes linked to depression: reward processing and stress sensitivity. A synthesis of this burgeoning literature indicates that a molecular genetic approach focused on intermediate phenotypes holds significant promise to fundamentally improve our understanding of the pathophysiology and etiology of depression, which will be required for improved diagnostic definitions and the development of novel and more efficacious treatment and prevention strategies. We conclude by highlighting challenges facing intermediate phenotype research and future development that will be required to propel this pivotal research into new directions. (C) 2012 Elsevier Inc. All rights reserved.

【 授权许可】

Free