Ionic and synaptic mechanisms of seizure generation and epileptogenesis

NEUROBIOLOGY OF DISEASE

卷:130

Review

Gonzalez, Oscar C.^1,2  Krishnan, Giri P.²  Timofeev, Igor^3,4  Bazhenov, Maxim^1,2 

[1] Univ Calif San Diego, Neurosci Grad Program, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

[3] CRIUSMQ, 2601 Canardiere, Quebec City, PQ, Canada

[4] Univ Laval, Dept Psychiat & Neurosci, Quebec City, PQ, Canada

关键词: Ion concentration dynamics;    Homeostatic synaptic plasticity;    Epileptic seizures;    Computational model;   

DOI  :  10.1016/j.nbd.2019.104485

来源: Elsevier

【 摘 要 】

The biophysical mechanisms underlying epileptogenesis and the generation of seizures remain to be better understood. Among many factors triggering epileptogenesis are traumatic brain injury breaking normal synaptic homeostasis and genetic mutations disrupting ionic concentration homeostasis. Impairments in these mechanisms, as seen in various brain diseases, may push the brain network to a pathological state characterized by increased susceptibility to unprovoked seizures. Here, we review recent computational studies exploring the roles of ionic concentration dynamics in the generation, maintenance, and termination of seizures. We further discuss how ionic and synaptic homeostatic mechanisms may give rise to conditions which prime brain networks to exhibit recurrent spontaneous seizures and epilepsy.

【 授权许可】

Free