Sex, epilepsy, and epigenetics

NEUROBIOLOGY OF DISEASE

卷:72

Review

Qureshi, Irfan A.^1,2,3,6  Mehler, Mark F.^{1,2,3,4,5,6,7,8,9,10} 

[1] Albert Einstein Coll Med, Roslyn & Leslie Goldstein Lab Stem Cell Biol & Re, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Inst Brain Disorders & Neural Regenerat, Bronx, NY 10461 USA

[3] Albert Einstein Coll Med, Dept Neurol, Bronx, NY 10461 USA

[4] Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA

[5] Albert Einstein Coll Med, Dept Psychiat & Behav Sci, Bronx, NY 10461 USA

[6] Albert Einstein Coll Med, Rose Kennedy Ctr Res Intellectual & Dev Disabil, Bronx, NY 10461 USA

[7] Albert Einstein Coll Med, Einstein Canc Ctr, Bronx, NY 10461 USA

[8] Albert Einstein Coll Med, Ruth S & David L Gottesman Stem Cell Inst, Bronx, NY 10461 USA

[9] Albert Einstein Coll Med, Ctr Epigen, Bronx, NY 10461 USA

[10] Albert Einstein Coll Med, Inst Aging Res, Bronx, NY 10461 USA

关键词: Chromatin;    DNA methylation;    Epigenetic;    Epilepsy;    Histone;    Non-coding RNA;   

DOI  :  10.1016/j.nbd.2014.06.019

来源: Elsevier

【 摘 要 】

Epilepsy refers to a heterogeneous group of disorders that are associated with a wide range of pathogenic mechanisms, seizure manifestations, comorbidity profiles, and therapeutic responses. These characteristics are all influenced quite significantly by sex. As with other conditions exhibiting such patterns, sex differences in epilepsy are thought to arise-at the most fundamental level-from the organizational and activational effects of sex hormones as well as from the direct actions of the sex chromosomes. However, our understanding of the specific molecular, cellular, and network level processes responsible for mediating sex differences in epilepsy remains limited. Because increasing evidence suggests that epigenetic mechanisms are involved both in epilepsy and in brain sexual dimorphism, we make the case here that analyzing epigenetic regulation will provide novel insights into the basis for sex differences in epilepsy. (C) 2014 Elsevier Inc. All rights reserved.

【 授权许可】

Free