Heme oxygenase 1 is associated with ischemic preconditioning-induced protection against brain ischemia

NEUROBIOLOGY OF DISEASE

卷:35

Article

Zeynalov, Emil¹  Shah, Zahoor A.¹  Li, Rung-chi¹  Dore, Sylvain¹ 

[1] Johns Hopkins Univ, Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21205 USA

关键词: Heme oxygenase;    Ischemic preconditioning;    Middle cerebral artery occlusion;    Neuroprotection;    Permanent middle cerebral artery occlusion;   

DOI  :  10.1016/j.nbd.2009.05.010

来源: Elsevier

【 摘 要 】

Ischemic preconditioning (IPC) protects brain against ischemic injury by activating specific mechanisms. Our goal was to determine if the inducible heme oxygenase 1 (HO1) is required for such protection. IPC before transient or permanent ischemia reduced cortical infarct volumes by 57.4% and 33.9%, respectively at 48 h in wildtype adult mice. Interestingly, IPC failed to protect the HO1 gene deleted mice against permanent ischemic brain injury. IPC also resulted in a significant increase in HO1 protein levels in the brain and correlated with reduced neurological deficits after permanent and transient brain ischemia. Our study demonstrates that neuroprotective effects of IPC are at least partially mediated via HO1. Elucidating the physiological/cellular role by which HO1 is protective against brain ischemia may aid the development of selective drugs to treat stroke and its associated neurological disorders. (C) 2009 Elsevier Inc. All rights reserved.

【 授权许可】

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