Nuclear receptors in neurodegenerative diseases

NEUROBIOLOGY OF DISEASE

卷:72

Review

Skerrett, Rebecca¹  Malm, Tarja^1,2  Landreth, Gary¹ 

[1] Case Western Reserve Univ, Sch Med, Dept Neurosci, Cleveland, OH 44106 USA

[2] Univ Eastern Finland, Dept Neurobiol, AI Virtanen Inst Mol Sci, Kuopio 70211, Finland

关键词: Nuclear receptors;    Peroxisome proliferator-activated receptors;    Liver X receptors;    Retinoid X receptors;    Microglia;    Inflammation;    Neurodegeneration;    Alzheimer's disease;    Parkinson's disease;    Amyotrophic lateral sclerosis;    Huntington's disease;   

DOI  :  10.1016/j.nbd.2014.05.019

来源: Elsevier

【 摘 要 】

Nuclear receptors have generated substantial interest in the past decade as potential therapeutic targets for the treatment of neurodegenerative disorders. Despite years of effort, effective treatments for progressive neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease and ALS remain elusive, making non-classical drug targets such as nuclear receptors an attractive alternative. A substantial literature in mouse models of disease and several clinical trials have investigated the role of nuclear receptors in various neurodegenerative disorders, most prominently AD. These studies have met with mixed results, yet the majority of studies in mouse models report positive outcomes. The mechanisms by which nuclear receptor agonists affect disease pathology remain unclear. Deciphering the complex signaling underlying nuclear receptor action in neurodegenerative diseases is essential for understanding this variability in preclinical studies, and for the successful translation of nuclear receptor agonists into clinical therapies. (C) 2014 Elsevier Inc. All rights reserved.

【 授权许可】

Free