Pregabalin suppresses calcium-mediated proteolysis and improves stroke outcome

NEUROBIOLOGY OF DISEASE

卷:41

Article

Yoon, Jeong Sean¹  Lee, Jong-Hwan¹  Son, Tae Gen¹  Mughal, Mohamed R.¹  Greig, Nigel H.¹  Mattson, Mark P.¹ 

[1] NIA, Neurosci Lab, Intramural Res Program, Baltimore, MD 21224 USA

关键词: Calcium;    Calpain;    Cerebral ischemia;    Neuronal death;    Pregabalin;    Presynaptic calcium channels;   

DOI  :  10.1016/j.nbd.2010.11.011

来源: Elsevier

【 摘 要 】

Pregabalin, a Ca2+ channel alpha(2)delta-subunit antagonist with analgesic and antiepileptic activity, reduced neuronal loss and improved functional outcome in a mouse model of focal ischemic stroke. Pregabalin administration (5-10 mg/kg, i.p.) 30-90 min after transient middle cerebral artery occlusion/reperfusion reduced infarct volume, neuronal death in the ischemic penumbra and neurological deficits at 24 h post-stroke. Pregabalin significantly decreased the amount of Ca2+/calpain-mediated et-spectrin proteolysis in the cerebral cortex measured at 6 h post-stroke. Together with the extensive clinical experience with pregabalin for other neurological indications, our findings suggest the potential for a therapeutic benefit of pregabalin in stroke patients. (C) 2010 Published by Elsevier Inc.

【 授权许可】

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