Hippocampal and ventricular changes in Parkinson's disease mild cognitive impairment

NEUROBIOLOGY OF AGING

卷:33

Article

Apostolova, Liana^1,2  Alves, Guido^3,4  Hwang, Kristy S.^1,2  Babakchanian, Sona^1,2  Bronnick, Kolbjorn S.³  Larsen, Jan Petter³  Thompson, Paul M.^1,2  Chou, Yi-Yu^1,2  Tysnes, Ole B.⁵  Vefring, Hege K.⁶  Beyer, Mona K.⁷ 

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Lab Neuro Imaging, Los Angeles, CA 90095 USA

[3] Stavanger Univ Hosp, Norwegian Ctr Movement Disorders, Stavanger, Norway

[4] Stavanger Univ Hosp, Dept Neurol, Stavanger, Norway

[5] Haukeland Hosp, Dept Neurol, N-5021 Bergen, Norway

[6] Stavanger Univ Hosp, Dept Med Biochem, Stavanger, Norway

[7] Stavanger Univ Hosp, Dept Radiol, Stavanger, Norway

关键词: Parkinson disease;    Mild cognitive impairment;    MCI;    Brain atrophy;    Hippocampal atrophy;    Ventricular enlargement;    Magnetic resonance imaging;    MRI;    Cognitive correlations;    Dementia;    Cognition;   

DOI  :  10.1016/j.neurobiolaging.2011.06.014

来源: Elsevier

【 摘 要 】

We analyzed T1-weighted brain magnetic resonance imaging data of 100 cognitively normal elderly controls (NC), 127 cognitively normal Parkinson's disease (PD; PDCN) and 31 PD-associated mild cognitive impairment (PDMCI) subjects from the Norwegian ParkWest study. Using automated segmentation methods, followed by the radial distance technique and multiple linear regression we studied the effect of clinical diagnosis on hippocampal and ventricular radial distance while adjusting for age, education, and scanning site. PDCN subjects had significantly smaller bilateral hippocampal radial distance relative to NC. Nonamnestic PDMCI subjects showed smaller right hippocampal radial distance relative to NC. PDMCI subjects showed significant enlargement of all portions of the lateral ventricles relative to NC and significantly larger bilateral temporal and occipital and left frontal lateral ventricular expansion relative to PDCN subjects. Nonamnestic PDMCI subjects showed significant ventricular enlargement spanning all parts of the lateral ventricle while those with amnestic PDMCI showed changes localized to the left occipital horn. Hippocampal atrophy and lateral ventricular enlargement show promise as structural biomarkers for PD. (C) 2012 Elsevier Inc. All rights reserved.

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