Cooccurrence of vascular risk factors and late-life white-matter integrity changes

NEUROBIOLOGY OF AGING

卷:36

Article

Maillard, Pauline^1,2,3  Carmichael, Owen T.^1,2,3  Reed, Bruce^1,2,3  Mungas, Dan^1,2,3  DeCarli, Charles^1,2,3 

[1] Univ Calif Davis, Imaging Dementia & Aging IDeA Lab, Davis, CA 95616 USA

[2] Univ Calif Davis, Dept Neurol, Davis, CA 95616 USA

[3] Univ Calif Davis, Ctr Neurosci, Davis, CA 95616 USA

关键词: Diffusion tensor imaging;    Diabetes;    Hypertension;    Hyperlipidemia;    Aging;    White matter;   

DOI  :  10.1016/j.neurobiolaging.2015.01.007

来源: Elsevier

【 摘 要 】

Hypertension, hyperlipidemia, and diabetes are increasingly prevalent with advancing age and have been shown to cause white-matter (WM) injury that may contribute to dementia risk. However, cumulative and over time effects of these medical illnesses have not been systematically examined. One hundred twenty-one cognitively normal old participants received comprehensive clinical evaluations and brain diffusion tensor imaging on 2 occasions. Clinical history and medical treatment of diabetes, hypertension, and hyperlipidemia were assessed at both evaluations. We examined whether exposure to a greater number of vascular risk factors (VRFs) was associated with greater rate of WM integrity change using longitudinal differences in fractional anisotropy (FA). Compared with individuals with no VRF, individuals with 1 VRF did not exhibit significantly different change in FA. However, those with >= 2 VRFs had greater decrease in FA within multiple WM regions including the splenium of the corpus callosum. The accumulation of VRF increasingly affected WM integrity, particularly in areas known to be injured in patients with mild cognitive impairment and dementia. (C) 2015 Elsevier Inc. All rights reserved.

【 授权许可】

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