Association of white matter microstructural integrity with cognition and dementia

NEUROBIOLOGY OF AGING

卷:83

Article

Power, Melinda C.¹  Su, Dan²  Wu, Aozhou³  Reid, Robert I.⁴  Jack, Clifford R.⁵  Knopman, David S.⁶  Coresh, Joe³  Huang, Juebin⁷  Kantarci, Kejal⁵  Sharrett, A. Richey³  Gottesman, Rebecca G.^3,8  Griswold, Mike E.²  Mosley, Thomas H.^7,9 

[1] George Washington Univ, Milken Inst Sch Publ Hlth, Dept Epidemiol & Biostat, 950 New Hampshire Ave NW, Washington, DC 20052 USA

[2] Univ Mississippi, Med Ctr, JD Bower Sch Populat Hlth, Dept Data Sci, Jackson, MS 39216 USA

[3] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[4] Mayo Clin, Dept Informat Technol, Rochester, MN USA

[5] Mayo Clin, Dept Radiol, Rochester, MN USA

[6] Mayo Clin, Dept Neurol, Rochester, MN USA

[7] Univ Mississippi, Med Ctr, Dept Neurol, Jackson, MS 39216 USA

[8] Johns Hopkins Univ, Dept Neurol, Baltimore, MD 21218 USA

[9] Univ Mississippi, Med Ctr, Dept Geriatr, Jackson, MS 39216 USA

关键词: Dementia;    White matter microstructural integrity;    Cognitive impairment;    DTI;    MRI;    Cognitive decline;   

DOI  :  10.1016/j.neurobiolaging.2019.08.021

来源: Elsevier

【 摘 要 】

Late-life measures of white matter (WM) microstructural integrity may predict cognitive status, cognitive decline, and incident mild cognitive impairment (MCI) or dementia. We considered participants of the Atherosclerosis Risk in Communities study who underwent cognitive assessment and neuroimaging in 2011-2013 and were followed through 2016-2017 (n = 1775 for analyses of prevalent MCI and dementia, baseline cognitive performance, and longitudinal cognitive change and n = 889 for analyses of incident MCI, dementia, or death). Cross-sectionally, both overall WM fractional anisotropy and overall WM mean diffusivity were strongly associated with baseline cognitive performance and risk of prevalent MCI or dementia. Longitudinally, greater overall WM mean diffusivity was associated with accelerated cognitive decline, as well as incident MCI, incident dementia, and mortality, but WM fractional anisotropy was not robustly associated with cognitive change or incident cognitive impairment. Both cross-sectional and longitudinal associations were attenuated after additionally adjusting for likely downstream pathologic changes. Increased WM mean diffusivity may provide an early indication of dementia pathogenesis. (C) 2019 Elsevier Inc. All rights reserved.

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