Thickness network features for prognostic applications in dementia

NEUROBIOLOGY OF AGING

卷:36

Article

Raamana, Pradeep Reddy¹  Weiner, Michael W.²  Wang, Lei³  Beg, Mirza Faisal¹ 

[1] Simon Fraser Univ, Sch Engn Sci, Dept Engn Sci, Burnaby, BC V5A 1S6, Canada

[2] Univ Calif San Francisco, Dept Radiol, Ctr Imaging Neurodegenerat Dis, San Francisco, CA USA

[3] Northwestern Univ, Dept Med, Feinberg Sch Med, Chicago, IL 60611 USA

关键词: Cortical thickness;    Network properties;    Fusion;    Multiple kernel learning;    Early detection;    Mild cognitive impairment;    Alzheimer;   

DOI  :  10.1016/j.neurobiolaging.2014.05.040

来源: Elsevier

【 摘 要 】

Regional analysis of cortical thickness has been studied extensively in building imaging biomarkers for early detection of Alzheimer's disease but not its interregional covariation of thickness. We present novel features based on the inter-regional covariation of cortical thickness. Initially, the cortical labels of each subject are partitioned into small patches (graph nodes) by spatial k-means clustering. A graph is then constructed by establishing a link between 2 nodes if the difference in thickness between the nodes is below a certain threshold. From this binary graph, a thickness network is computed using nodal degree, betweenness, and clustering coefficient measures. Fusing them with multiple kernel learning, it is observed that thickness network features discriminate mild cognitive impairment (MCI) converters from controls (CN) with an area under curve (AUC) of 0.83, 74% sensitivity and 76% specificity on a large subset obtained from the Alzheimer's Disease Neuroimaging Initiative data set. A comparison of predictive utility in Alzheimer's disease and/or CN classification (AUC of 0.92, 80% sensitivity [SENS] and 90% specificity [SPEC]), in discriminating CN from MCI (converters and nonconverters combined; AUC of 0.75, SENS and SPEC of 64% and 73%, respectively) and in discriminating between MCI nonconverters and MCI converters (AUC of 0.68, SENS and SPEC of 65% and 64%) is also presented. ThickNet features as defined here are novel, can be derived from a single magnetic resonance imaging scan, and demonstrate the potential for the computer-aided prognostic applications. (C) 2015 Elsevier Inc. All rights reserved.

【 授权许可】

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