Ex vivo T2 relaxation: associations with age-related neuropathology and cognition

NEUROBIOLOGY OF AGING

卷:35

Article

Dawe, Robert J.^1,2  Bennett, David A.^1,3  Schneider, Julie A.^1,3,4  Leurgans, Sue E.^1,3  Kotrotsou, Aikaterini⁵  Boyle, Patricia A.^1,6  Arfanakis, Konstantinos^1,2,5 

[1] Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA

[2] Rush Univ, Med Ctr, Dept Diagnost Radiol & Nucl Med, Chicago, IL 60612 USA

[3] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA

[4] Rush Univ, Med Ctr, Dept Pathol, Chicago, IL 60612 USA

[5] IIT, Dept Biomed Engn, Chicago, IL 60616 USA

[6] Rush Univ, Med Ctr, Dept Behav Sci, Chicago, IL 60612 USA

关键词: Neuroimaging;    MRI;    Gross infarct;    Hippocampal sclerosis;    Cognition;    Voxelwise;   

DOI  :  10.1016/j.neurobiolaging.2014.01.144

来源: Elsevier

【 摘 要 】

The transverse relaxation time constant, T-2, is sensitive to brain tissue's free water content and the presence of paramagnetic materials such as iron. In this study, ex vivo magnetic resonance imaging was used to investigate alterations in T-2 related to Alzheimer's disease (AD) pathology and other types of neuropathology common in old age, as well as the relationship between T-2 alterations and cognition. Cerebral hemispheres were obtained from 371 deceased older adults. Using fast spin-echo imaging with multiple echo times, T-2 maps were produced and warped to a study-specific template. Hemispheres underwent neuropathologic examination for identification of AD pathology and other common age-related neuropathologies. Voxelwise linear regression was carried out to detect regions of pathology-related T-2 alterations and, in separate analyses, regions in which T-2 alterations were linked to antemortem cognitive performance. AD pathology was associated with T-2 prolongation in white matter of all lobes and T-2 shortening in the basal ganglia and insula. Gross infarcts were associated with T-2 prolongation in white matter of all lobes, and in the thalamus and basal ganglia. Hippocampal sclerosis was associated with T-2 prolongation in the hippocampus and white matter of the temporal lobe. After controlling for neuropathology, T-2 prolongation in the frontal lobe white matter was associated with lower performance in the episodic, semantic, and working memory domains. In addition, voxelwise analysis of in vivo and ex vivo T-2 values indicated a positive relationship between the two, though further investigation is necessary to accurately translate findings of the present study to the in vivo case. (C) 2014 Elsevier Inc. All rights reserved.

【 授权许可】

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