Brain-predicted age in Down syndrome is associated with beta amyloid deposition and cognitive decline

NEUROBIOLOGY OF AGING

卷:56

Article

Cole, James H.¹  Annus, Tiina²  Wilson, Liam R.²  Remtulla, Ridhaa³  Hong, Young T.⁴  Fryer, Tim D.⁴  Acosta-Cabronero, Julio⁵  Cardenas-Blanco, Arturo⁵  Smith, Robert⁴  Menon, David K.⁶  Zaman, Shahid H.²  Nestor, Peter J.⁵  Holland, Anthony J.² 

[1] Imperial Coll London, Div Brain Sci, C3NL, London, England

[2] Univ Cambridge, Dept Psychiat, Cambridge Intellectual & Dev Disabil Res Grp, Cambridge, England

[3] Univ Birmingham, Med Sch, Birmingham, W Midlands, England

[4] Univ Cambridge, Wolfson Brain Imaging Ctr, Cambridge, England

[5] German Ctr Neurodegenerat Dis DZNE, Magdeburg, Germany

[6] Univ Cambridge, Dept Med, Div Anaesthesia, Cambridge, England

关键词: Down syndrome;    Brain aging;    Amyloid PET;    MRI;    Machine learning;    Cognitive decline;   

DOI  :  10.1016/j.neurobiolaging.2017.04.006

来源: Elsevier

【 摘 要 】

Individuals with Down syndrome (DS) are more likely to experience earlier onset of multiple facets of physiological aging. This includes brain atrophy, beta amyloid deposition, cognitive decline, and Alzheimer's diseased-factors indicative of brain aging. Here, we employed a machine learning approach, using structural neuroimaging data to predict age (i.e., brain-predicted age) in people with DS (N = 46) and typically developing controls (N = 30). Chronological age was then subtracted from brain-predicted age to generate a brain-predicted age difference (brain-PAD) score. DS participants also underwent [C-11]-PiB positron emission tomography (PET) scans to index the levels of cerebral beta amyloid deposition, and cognitive assessment. Mean brain-PAD in DS participants' was +2.49 years, significantly greater than controls (p < 0.001). The variability in brain-PAD was associated with the presence and the magnitude of PiB-binding and levels of cognitive performance. Our study indicates that DS is associated with premature structural brain aging, and that age-related alterations in brain structure are associated with individual differences in the rate of beta amyloid deposition and cognitive impairment. (C) 2017 The Authors. Published by Elsevier Inc.

【 授权许可】

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