Relationship between inferior frontal sulcal hyperintensities on brain MRI, ageing and cerebral small vessel disease

NEUROBIOLOGY OF AGING

卷:106

Article

Zhang, Jun-Fang^1,2,3  Lim, Hwee Fang⁴  Chappell, Francesca M.^2,3  Clancy, Una^2,3  Wiseman, Stewart^2,3  Valdes-Hernandez, Maria C.^2,3  Garcia, Daniela Jaime^2,3  Bastin, Mark E.^2,3  Doubal, Fergus N.^2,3  Hewins, Will^2,3  Cox, Simon R.⁵  Maniega, Susana Munoz^2,3  Thrippleton, Michael^2,3  Stringer, Michael^2,3  Jardine, Charlotte⁶  McIntyre, Donna⁶  Barclay, Gayle⁶  Hamilton, Iona⁶  Kesseler, Lucy⁶  Murphy, Madeleine⁶  Di Perri, Carol^2,3  Wu, Yun-Cheng¹  Wardlaw, Joanna M.^2,3 

[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Gen Hosp, Dept Neurol, 86 Wujin Rd, Shanghai 200080, Peoples R China

[2] Univ Edinburgh, Edinburgh Imaging, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland

[3] Univ Edinburgh, UK Dementia Res Inst, Edinburgh, Midlothian, Scotland

[4] NHS Lothian, Dept Radiol, Edinburgh, Midlothian, Scotland

[5] Univ Edinburgh, Dept Psychol, Edinburgh, Midlothian, Scotland

[6] Univ Edinburgh, Edinburgh Imaging RIE, Edinburgh, Midlothian, Scotland

关键词: Cerebral small vessel disease;    Fluid-attenuated inversion recovery;    Glymphatic system;    Magnetic resonance imaging;    Perivascular spaces;   

DOI  :  10.1016/j.neurobiolaging.2021.06.013

来源: Elsevier

【 摘 要 】

Raised signal in cerebrospinal fluid (CSF) on fluid-attenuated inversion recovery (FLAIR) may indicate raised CSF protein or debris and is seen in inferior frontal sulci on routine MRI. To explore its clinical rel-evance, we assessed the association of inferior frontal sulcal hyperintensities (IFSH) on FLAIR with demo-graphics, risk factors, and small vessel disease markers in three cohorts (healthy volunteers, n = 44; mild stroke patients, n = 105; older community-dwelling participants from Lothian birth cohort 1936, n = 101). We collected detailed clinical data, scanned all subjects on the same 3T MRI scanner and 3-dimensional FLAIR sequence and developed a scale to rate IFSH. In adjusted analyses, the IFSH score increased with age (per 10-year increase; OR 1.69; 95% CI, 1.42-2.02), and perivascular spaces score in centrum semio-vale in stroke patients (OR 1.73; 95% CI, 1.13-2.69). Since glymphatic CSF clearance declines with age and drains partially via the cribriform plate to the nasal lymphatics, IFSH on 3T MRI may be a non-invasive biomarker of altered CSF clearance and justifies further research in larger, more diverse samples. (c) 2021 Elsevier Inc. All rights reserved.

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