Lack of limbic-predominant age-related TDP-43 encephalopathy (LATE) neuropathological changes in aged macaques with memory impairment

NEUROBIOLOGY OF AGING

卷:107

Article

Darricau, Morgane¹  Canron, Marie-Helene¹  Bosc, Marion²  Arotcarena, Marie-Laure¹  Le Quang, Megane¹  Dehay, Benjamin¹  Bezard, Erwan^1,2  Planche, Vincent^1,3 

[1] Univ Bordeaux, IMN, CNRS, UMR 5293, Bordeaux, France

[2] Motac Neurosci, Bordeaux, France

[3] Ctr Memoire Ressources Rech, Pole Neurosci Clin, Bordeaux, France

关键词: TDP-43;    LATE;    Aging;    Non-human primate;   

DOI  :  10.1016/j.neurobiolaging.2021.07.009

来源: Elsevier

【 摘 要 】

The neuropathological changes of limbic-predominant age-related TDP-43 encephalopathy (LATE) are frequent in the aged population and are now recognized as a cause of memory impairment. However, it remains unknown if this proteinopathy is also present in other primate species. We thus investigated the presence and distribution of TDP-43 pathology in the hippocampus and amygdala of 7 aged memoryimpaired rhesus macaques ( Macaca mulatta, 18-32 years old) from 2 different cohorts. While present in an FTLD-TDP case used as a positive control for immunostaining, we found no TDP-43 or phosphorylated TDP-43 immunoreactive neuronal cytoplasmic inclusion in the amygdala or the hippocampus of these aged animals (as well as in young and mature macaques used as negative controls). We concluded that LATE is probably a human-specific condition, such as many other proteinopathies, and does not participate in age-related memory impairment in non-human primates. (c) 2021 Elsevier Inc. All rights reserved.

【 授权许可】

Free