Lifestyle and the aging brain: interactive effects of modifiable lifestyle behaviors and cognitive ability in men from midlife to old age

NEUROBIOLOGY OF AGING

卷:108

Article

Franz, Carol E.^1,2  Hatton, Sean N.³  Elman, Jeremy A.¹  Warren, Teresa⁴  Gillespie, Nathan A.⁶  Whitsel, Nathan A.^1,2  Puckett, Olivia K.^1,2  Dale, Anders M.³  Eyler, Lisa T.^1,2  Fennema-Notestine, Christine^1,2,3  Hagler, Donald J., Jr.³  McKenzie, Ruth⁶  Neale, Michael C.⁵  Panizzon, Matthew S.^1,2  Pearce, Rahul C.^1,2  Reynolds, Chandra A.⁷  Sanderson-Cimino, Mark^8,11  Toomey, Rosemary⁶  Tu, Xin M.⁹  Williams, McKenna^1,2  Xian, Hong^8,10  Lyons, Michael J.⁶  Kremen, William S.^1,2 

[1] Univ Calif San Diego, Dept Psychiat, 9500 Gilman Dr,MC 0738, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Ctr Behav Genet Aging, San Diego, CA 92103 USA

[3] Univ Calif San Diego, Dept Radiol, San Diego, CA 92103 USA

[4] San Diego State Univ, Dept Psychol, San Diego, CA 92182 USA

[5] Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Dept Psychiat, Richmond, VA USA

[6] QIMR Berghofer Med Res Inst, Herston, Qld, Australia

[7] Boston Univ, Dept Psychol & Brain Sci, Boston, MA 02215 USA

[8] Univ Calif Riverside, Dept Psychol, Riverside, CA 92521 USA

[9] Univ Calif San Diego, San Diego State Univ, Joint Doctoral Program Clin Psychol, San Diego, CA 92103 USA

[10] Univ Calif San Diego, Dept Family Med, San Diego, CA 92103 USA

[11] St Louis Univ, Dept Epidemiol & Biostat, St Louis, MO 63103 USA

关键词: General cognitive ability;    Modifiable lifestyle behavior;    Brain aging;    Alzheimer's disease brain signature;    Mild cognitive impairment;    White matter abnormalities;    Cognitive reserve;   

DOI  :  10.1016/j.neurobiolaging.2021.08.007

来源: Elsevier

【 摘 要 】

We examined the influence of lifestyle on brain aging after nearly 30 years, and tested the hypothesis that young adult general cognitive ability (GCA) would moderate these effects. In the community dwelling Vietnam Era Twin Study of Aging (VETSA), 431 largely non-Hispanic white men completed a test of GCA at mean age 20. We created a modifiable lifestyle behavior composite from data collected at mean age 40. During VETSA, MRI-based measures at mean age 68 included predicted brain age difference (PBAD), Alzheimer's disease (AD) brain signature, and abnormal white matter scores. There were significant main effects of young adult GCA and lifestyle on PBAD and the AD signature (ps < 0.012), and a GCA-by-lifestyle interaction on both (ps < 0.006). Regardless of GCA level, having more favorable lifestyle behaviors predicted less advanced brain age and less AD-like brain aging. Unfavorable lifestyles predicted advanced brain aging in those with lower age 20 GCA, but did not affect brain aging in those with higher age 20 GCA. Targeting early lifestyle modification may promote dementia risk reduction, especially among lower reserve individuals. (c) 2021 Published by Elsevier Inc.

【 授权许可】

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