Dietary energy intake modifies brainstem autonomic dysfunction caused by mutant α-synuclein

NEUROBIOLOGY OF AGING

卷:34

Article

Griffioen, Kathleen J.¹  Rothman, Sarah M.¹  Ladenheim, Bruce²  Wan, Ruiqian¹  Vranis, Neil¹  Hutchison, Emmette¹  Okun, Eitan^1,3  Cadet, Jean Lud²  Mattson, Mark P.^1,4 

[1] NIA, Intramural Res Program, Neurosci Lab, Baltimore, MD 21224 USA

[2] NIDA, Mol Neuropsychiat Branch, Intramural Res Program, Baltimore, MD USA

[3] Bar Ilan Univ, Fac Life Sci, Ramat Gan, Israel

[4] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

关键词: alpha-synuclein;    Acetylcholine;    ANS;    BDNF;    Brainstem;    Parasympathetic;    Parkinson's disease;   

DOI  :  10.1016/j.neurobiolaging.2012.07.008

来源: Elsevier

【 摘 要 】

Parkinson's disease (PD) patients often exhibit impaired regulation of heart rate by the autonomic nervous system (ANS) that may precede motor symptoms in many cases. Results of autopsy studies suggest that brainstem pathology, including the accumulation of alpha-synuclein, precedes damage to dopaminergic neurons in the substantia nigra in PD. However, the molecular and cellular mechanisms responsible for the early dysfunction of brainstem autonomic neurons are unknown. Here we report that mice expressing a mutant form of alpha-synuclein that causes familial PD exhibit aberrant autonomic control of the heart characterized by elevated resting heart rate and an impaired cardiovascular stress response, associated with reduced parasympathetic activity and accumulation of alpha-synuclein in the brainstem. These ANS abnormalities occur early in the disease process. Adverse effects of alpha-synuclein on the control of heart rate are exacerbated by a high energy diet and ameliorated by intermittent energy restriction. Our findings establish a mouse model of early dysregulation of brainstem control of the cardiovascular system in PD, and further suggest the potential for energy restriction to attenuate ANS dysfunction, particularly in overweight individuals. Published by Elsevier Inc.

【 授权许可】

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