Association of telomere length with general cognitive trajectories: a meta-analysis of four prospective cohort studies

NEUROBIOLOGY OF AGING

卷:69

Article

Zhan, Yiqiang¹  Clements, Mark S.¹  Roberts, Rosebud O.^2,3  Vassilaki, Maria²  Druliner, Brooke R.⁴  Boardman, Lisa A.⁴  Petersen, Ronald C.^2,3  Reynolds, Chandra A.⁵  Pedersen, Nancy L.¹  Hagg, Sara¹ 

[1] Karolinska Inst, Dept Med Epidemiol & Biostat, Nobels Vag 12A, S-17177 Stockholm, Sweden

[2] Mayo Clin, Div Epidemiol, Dept Hlth Sci Res, Rochester, MN USA

[3] Mayo Clin, Dept Neurol, Rochester, MN USA

[4] Mayo Clin, Dept Internal Med, Rochester, MN USA

[5] Univ Calif Riverside, Dept Psychol, Riverside, CA 92521 USA

关键词: Telomere;    Cognition;    Biological aging;    Cognitive aging;   

DOI  :  10.1016/j.neurobiolaging.2018.05.004

来源: Elsevier

【 摘 要 】

To investigate the association of telomere length (TL) with trajectories of general cognitive abilities, we used data on 5955 participants from the Sex Differences in Health and Aging Study and the Swedish Adoption/Twin Study of Aging in Sweden, and the Mayo Clinic Study of Aging, and the Health and Retirement Study in the United States. TL was measured at baseline, while general cognitive ability was assessed repeatedly up to 7 occasions. Latent growth curve models were used to examine the associations. One standard deviation increase of TL was associated with 0.021 unit increase (95% confidence interval [CI]: 0.001, 0.042) of standardized mean general cognitive ability. After controlling for sex, the point estimate remained similar (0.019) with a wider CI (95% CI: -0.002, 0.039). The association was attenuated with adjustment for educational attainment (0.009, 95% CI: -0.009, 0.028). No strong evidence was observed for the association of TL and decline in general cognitive ability. Longer TL was associated with higher general cognitive ability levels in the age-adjusted models but not in the models including all covariates, nor with cognitive decline. (C) 2018 Elsevier Inc. All rights reserved.

【 授权许可】

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