Regional age-related effects in the monkey brain measured with 1H magnetic resonance spectroscopy

NEUROBIOLOGY OF AGING

卷:32

Article

Ronen, Itamar^1,2  Fan, Xiaoying²  Schettler, Steve¹  Jain, Sahil^1,2  Murray, Donna¹  Kim, Dae-Shik^1,2  Killiany, Ronald^1,2  Rosene, Douglas¹ 

[1] Boston Univ, Sch Med, Dept Anat & Neurobiol, Boston, MA 02118 USA

[2] Boston Univ, Sch Med, Ctr Biomed Imaging, Boston, MA 02118 USA

关键词: Magnetic resonance spectroscopy;    Aging brain;    Rhesus monkey;    Brain metabolites;   

DOI  :  10.1016/j.neurobiolaging.2009.05.020

来源: Elsevier

【 摘 要 】

The rhesus monkey is a useful model for examining age-related effects on the brain, because of the extensive neuroanatomical homology between the monkey and the human brain, the tight control for neurological diseases as well as the possibility of obtaining relevant behavioral data and post-mortem tissue for histological analyses. Here, proton magnetic resonance spectroscopy (H-1-MRS) was used together with high-resolution anatomical MRI images to carefully assess regional concentrations of brain metabolites in a group of 20 rhesus monkeys. In an anterior volume of interest (VOI) that covered frontal and prefrontal areas, significant positive correlations of myo-inositol and of total creatine concentrations with age were detected, whereas N-acetyl aspartate (NAA) and choline compounds (Cho) were not significantly correlated with age. In an occipito-parietal VOI, all metabolites showed no statistically significant age-dependent trend. Strong correlations were found between NAA concentration and gray matter fraction in the VOIs as well as between choline compounds and white matter fraction. (C) 2009 Elsevier Inc. All rights reserved.

【 授权许可】

Free