Serum oxidized low-density lipoprotein level and risk of cognitive impairment in older women

NEUROBIOLOGY OF AGING

卷:34

Article

Koyama, Alain^1,2  Stone, Katie³  Yaffe, Kristine^2,4,5,6 

[1] No Calif Inst Res & Educ, San Francisco, CA USA

[2] San Francisco VA Med Ctr, San Francisco, CA USA

[3] Calif Pacific Med Ctr, Res Inst, San Francisco, CA USA

[4] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA

[5] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA

[6] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA

关键词: Dementia;    Alzheimer's disease;    Oxidized LDL;    Inflammation;    Oxidative stress;   

DOI  :  10.1016/j.neurobiolaging.2012.02.030

来源: Elsevier

【 摘 要 】

We investigated the association between serum level of oxidized low-density lipoprotein (oxLDL) and risk of cognitive impairment (dementia or mild cognitive impairment) among 572 nondemented community-dwelling women from a prospective cohort study of aging. After 5 years of follow-up, 228 (39.9%) developed cognitive impairment; and this did not differ by tertile of baseline oxLDL level (highest compared with lowest tertile 38.2% vs. 39.5%; odds ratio, 0.90; 95% confidence interval, 0.63-1.43). Multivariate adjustment produced similar results (odds ratio, 0.91; 95% confidence interval, 0.60-1.39). These findings suggest that increased levels of serum oxLDL are not associated with a greater risk of incident cognitive impairment in older women. (C) 2013 Elsevier Inc. All rights reserved.

【 授权许可】

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