NEUROBIOLOGY OF AGING | 卷:35 |
Critical levels of brain atrophy associated with homocysteine and cognitive decline | |
Review | |
de Jager, Celeste A.1  | |
[1] Univ Oxford, Nuffield Dept Clin Med, Oxford Project Invest Memory & Ageing, Oxford, England | |
关键词: Homocysteine; B vitamins; Folic acid; Cognition; Atrophy; Mild cognitive impairment; Alzheimer's disease; B12 deficiency; | |
DOI : 10.1016/j.neurobiolaging.2014.03.040 | |
来源: Elsevier | |
【 摘 要 】
Few B-vitamin trials to lower homocysteine (Hcy) have reported evidence of beneficial effects on cognition in older adults with cognitive impairment or Alzheimer's disease. This article reviews the role of Hcy in cognitive decline. It also considers some reasons why meta-analyses have failed to find effects of B-vitamin treatment. Findings from the successful VITACOG trial are examined from a new perspective of critical levels of Hcy and brain atrophy that may impact on the efficacy of B-vitamin treatment. It appears that there is a critical level of brain shrinkage, possibly mediated by elevated Hcy, which when reached, results in cognitive decline, especially in episodic memory performance. Supplements, food sources, and effects of folic acid fortification are discussed in relation to B12 deficiency. (C) 2014 Elsevier Inc. All rights reserved.
【 授权许可】
Free
【 预 览 】
Files | Size | Format | View |
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10_1016_j_neurobiolaging_2014_03_040.pdf | 158KB | download |