Feed efficiency, food choice, and food reward behaviors in young and old Fischer rats

NEUROBIOLOGY OF AGING

卷:33

Article

Garcia-San Frutos, Miriam^1,2  Pistell, Paul J.³  Ingram, Donald K.³  Berthoud, Hans-Rudolf² 

[1] Univ Rey Juan Carlos, Fac Hlth Sci, Dept Biochem Physiol & Mol Genet, Madrid 28922, Spain

[2] Louisiana State Univ, Pennington Biomed Res Ctr, Neurobiol Nutr Lab, Baton Rouge, LA 70808 USA

[3] Louisiana State Univ, Pennington Biomed Res Ctr, Nutr Neurosci & Aging Lab, Baton Rouge, LA 70808 USA

关键词: Aging;    Anorexia;    Palatability;    Appetite;    Gustation;    Reward;    Wanting;    Licking;    Learning;   

DOI  :  10.1016/j.neurobiolaging.2010.09.006

来源: Elsevier

【 摘 要 】

Increased susceptibility to energy imbalance and anorexia in old age are risk factors for malnutrition during aging, but the underlying mechanisms are not well understood. Here, we explored changes in taste-guided hedonic value (liking) and motivation to obtain (wanting) palatable foods as potential mediators of age-associated anorexia and weight loss in old Fischer-344 rats. Liking as measured by the number of positive hedonic orofacial responses to sucrose and corn oil was not different in old compared with young rats. Taste-guided, low effort wanting as measured by the number of licks per 10 seconds was also not different, although old rats exhibited a slight oromotor impairment as revealed by significantly increased interlick intervals. Medium effort wanting as measured by performance in the incentive runway was significantly decreased in old versus young rats. Although decreased net running speed was partially accountable, significantly increased duration of distractions suggested additional deficits in motivation and/or reinforcement learning. Together with early satiation on corn oil but not sucrose in aged rats, these changes are likely to have resulted in the significantly greater sucrose preference of old rats in 12-hour tests, and may ultimately lead to reduced energy intake and weight loss. (C) 2012 Elsevier Inc. All rights reserved.

【 授权许可】

Free