Cortical thinning of parahippocampal subregions in very early Alzheimer's disease

NEUROBIOLOGY OF AGING

卷:38

Article

Krumm, Sabine^1,2  Kivisaari, Sasa L.³  Probst, Alphonse^1,4  Monsch, Andreas U.^1,2  Reinhardt, Julia⁵  Ulmer, Stephan^6,7  Stippich, Christoph^2,5  Kressig, Reto W.^1,8  Taylor, Kirsten I.^1,2,9,10 

[1] Felix Platter Hosp, Univ Ctr Med Aging Basel, Memory Clin, Schanzenstr 55, CH-4031 Basel, Switzerland

[2] Univ Basel, Fac Psychol, Basel, Switzerland

[3] Aalto Univ, Sch Sci, Dept Neurosci & Biomed Engn, Aalto, Finland

[4] Univ Basel Hosp, Dept Neuropathol, Inst Pathol, CH-4031 Basel, Switzerland

[5] Univ Basel Hosp, Div Diagnost & Intervent Neuroradiol, Dept Radiol, CH-4031 Basel, Switzerland

[6] Univ Hosp Schleswig Holstein, Inst Neuroradiol, Kiel, Germany

[7] Mission Res Inc, Zurich, Switzerland

[8] Univ Basel, Fac Med, Basel, Switzerland

[9] Univ Cambridge, Dept Expt Psychol, Ctr Speech Language & Brain, Downing St, Cambridge CB2 3EB, England

[10] F Hoffmann La Roche Ltd, Biomarkers & Clin Imaging, Roche Innovat Ctr Basel, Roche Pharma Res & Early Dev,NORD, Grenzacherstr 124, CH-4070 Basel, Switzerland

关键词: Perirhinal cortex;    Entorhinal cortex;    Parahippocampal cortex;    Amnestic mild cognitive impairment;    Atrophy;    Structural MRI;   

DOI  :  10.1016/j.neurobiolaging.2015.11.001

来源: Elsevier

【 摘 要 】

The stereotypical pattern of neurofibrillary tangle spreading in the earliest stages of typical Alzheimer's dementia (AD) predicts that medial perirhinal cortex (mPRC) atrophy precedes entorhinal cortex (ERC) atrophy, whereas the status of the parahippocampal cortex (PHC) remains unclear. Atrophy studies have focused on more advanced rather than early AD patients, and usually segment the entire PRC as opposed to the mPRC versus lateral PRC (lPRC). The present study therefore determined the extent of ERC, mPRC, lPRC, and PHC atrophy in very early AD (mean Mini-Mental State Examination score = 26) patients and its presumed prodrome amnestic mild cognitive impairment (mean Mini-Mental State Examination score = 28) compared to demographically matched controls. PHG structures were manually segmented (blinded rater) and cortical thicknesses extracted. ERC and mPRC were similarly atrophied in both patient groups. The lPRC was atrophied in the AD group only. Thus, atrophic changes in very early AD broadly map onto the pattern of neurofibrillary tangle spreading and suggest that mPRC, ERC, and lPRC, but not PHC-associated functional impairments, characterize very early-stage AD. (C) 2016 The Authors. Published by Elsevier Inc.

【 授权许可】

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