Age-related decrease in cortical excitability circadian variations during sleep loss and its links with cognition

NEUROBIOLOGY OF AGING

卷:78

Article

Gaggioni, Giulia¹  Ly, Julien Q. M.^1,2  Muto, Vincenzo¹  Chellappa, Sarah L.^1,6,7  Jaspar, Mathieu^1,3  Meyer, Christelle¹  Delfosse, Tillo¹  Vanvinckenroye, Amaury¹  Dumont, Romain¹  't Wallant, Dorothee Coppieters¹  Berthomier, Christian⁴  Narbutas, Justinas¹  Van Egroo, Maxime¹  Luxen, Ande¹  Salmon, Eric^1,2,3  Collette, Fabienne^1,3  Phillips, Christophe^1,5  Schmidt, Christina^1,3  Vandewalle, Gilles¹ 

[1] Univ Liege, GIGA Inst, Vivo Imaging Sleep & Chronobiol Lab, Cyclotron Res Ctr, Liege, Belgium

[2] CHU Liege, Dept Neurol, Liege, Belgium

[3] Univ Liege, Fac Psychol & Educ Sci, Psychol & Neurosci Cognit Res Unit, Liege, Belgium

[4] Physip, Paris, France

[5] Univ Liege, GIGA Inst, Silico Med, Liege, Belgium

[6] Brigham & Womens Hosp, Dept Med, Div Sleep & Circadian Disorders, Med Chronobiol Program, 75 Francis St, Boston, MA 02115 USA

[7] Brigham & Womens Hosp, Dept Neurol, Div Sleep & Circadian Disorders, Med Chronobiol Program, 75 Francis St, Boston, MA 02115 USA

关键词: Aging;    Circadian;    Cognition;    Cortical excitability;    Sleep;   

DOI  :  10.1016/j.neurobiolaging.2019.02.004

来源: Elsevier

【 摘 要 】

Cortical excitability depends on sleep-wake regulation, is central to cognition, and has been implicated in age-related cognitive decline. The dynamics of cortical excitability during prolonged wakefulness in aging are unknown, however. Here, we repeatedly probed cortical excitability of the frontal cortex using transcranial magnetic stimulation and electroencephalography in 13 young and 12 older healthy participants during sleep deprivation. Although overall cortical excitability did not differ between age groups, the magnitude of cortical excitability variations during prolonged wakefulness was dampened in older individuals. This age-related dampening was associated with mitigated neurobehavioral consequences of sleep loss on executive functions. Furthermore, higher cortical excitability was potentially associated with better and lower executive performance, respectively, in older and younger adults. The dampening of cortical excitability dynamics found in older participants likely arises from a reduced impact of sleep homeostasis and circadian processes. It may reflect reduced brain adaptability underlying reduced cognitive flexibility in aging. Future research should confirm preliminary associations between cortical excitability and behavior and address whether maintaining cortical excitability dynamics can counteract age-related cognitive decline. (C) 2019 Elsevier Inc. All rights reserved.

【 授权许可】

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