Predictive cues and age-related declines in working memory performance

NEUROBIOLOGY OF AGING

卷:49

Article

Padgaonkar, Namita A.¹  Zanto, Theodore P.¹  Bollinger, Jacob¹  Gazzaley, Adam^1,2,3 

[1] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA

[2] Univ Calif San Francisco, Dept Physiol, Box 0444, San Francisco, CA USA

[3] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA

关键词: EEG;    Aging;    P3 amplitude;    Working memory;    Enhancement deficit;    Predictive information;   

DOI  :  10.1016/j.neurobiolaging.2016.09.002

来源: Elsevier

【 摘 要 】

Older adults, compared to younger adults, do not benefit from predictive information regarding either what type of stimuli they will see or when to expect them, yet it is unclear whether older adults benefit when given both types of predictive information. Here, electroencephalogram recordings of older (aged 62-87 years) and younger (aged 20-32 years) adults were recorded during a working memory task. Each trial contained 2 faces and 2 scenes presented sequentially, followed by a 5-second delay and a probe stimulus. Participants were told what stimuli to remember/ignore and when they would appear. Predictive cues enabled older adults to remember stimuli as accurately as younger adults, although response times were significantly slower, even when corrected for general age-related slowing. Previously observed reductions in P1/N1 amplitude and latency suppression to irrelevant stimuli were not seen. Rather, older adults exhibited lowered P3 amplitudes to relevant stimuli; those with the greatest declines yielded the lowest accuracy and slowest response times. This shows that predictive information can help maintain accuracy, although not response times, which correspond to age-related declines in neural enhancement to relevant stimuli. (C) 2016 Elsevier Inc. All rights reserved.

【 授权许可】

Free