Consistent neuroanatomical age-related volume differences across multiple samples

NEUROBIOLOGY OF AGING

卷:32

Article

Walhovd, Kristine B.^1,2  Westlye, Lars T.¹  Amlien, Inge¹  Espeseth, Thomas¹  Reinvang, Ivar¹  Raz, Naftali^3,4  Agartz, Ingrid^5,6,7  Fischl, Bruce⁸  Fjell, Anders M.^1,2 

[1] Univ Oslo, Dept Psychol, Ctr Study Human Cognit, N-0317 Oslo, Norway

[2] Ullevaal Univ Hosp, Dept Neuropsychol, Oslo, Norway

[3] Wayne State Univ, Dept Psychol, Detroit, MI 48202 USA

[4] Wayne State Univ, Inst Gerontol, Detroit, MI 48202 USA

[5] Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway

[6] Univ Oslo, Dept Psychiat, N-0317 Oslo, Norway

[7] Karolinska Hosp & Inst, Dept Clin Neurosci, Psychiat Sect, Stockholm, Sweden

[8] MIT, Comp Sci & Artificial Intelligence Lab, Cambridge, MA 02139 USA

关键词: MRI morphometry;    Age;    Cortex;    White matter;    Cerebellum;    Ventricles;    Hippocampus;    Amygdala;    Thalamus;    Basal ganglia;   

DOI  :  10.1016/j.neurobiolaging.2009.05.013

来源: Elsevier

【 摘 要 】

Magnetic resonance imaging (MRI) is the principal method for studying structural age-related brain changes in vivo. However, previous research has yielded inconsistent results, precluding understanding of structural changes of the aging brain. This inconsistency is due to methodological differences and/or different aging patterns across samples. To overcome these problems, we tested age effects on 17 different neuroanatomical structures and total brain volume across five samples, of which one was split to further investigate consistency (883 participants). Widespread age-related volume differences were seen consistently across samples. In four of the five samples, all structures, except the brainstem, showed age-related volume differences. The strongest and most consistent effects were found for cerebral cortex, pallidum, putamen and accumbens volume. Total brain volume, cerebral white matter, caudate, hippocampus and the ventricles consistently showed non-linear age functions. Healthy aging appears associated with more widespread and consistent age-related neuroanatomical volume differences than previously believed. (C) 2009 Elsevier Inc. All rights reserved.

【 授权许可】

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