Declines in inflammation predict greater white matter microstructure in older adults

NEUROBIOLOGY OF AGING

卷:36

Article

Bettcher, Brianne Magouirk¹  Yaffe, Kristine^2,3,4,5  Boudreau, Robert M.⁶  Neuhaus, John¹  Aizenstein, Howard⁷  Ding, Jingzhong⁸  Kritchevsky, Stephen B.⁸  Launer, Lenore J.⁹  Liu, Yongmei⁸  Satterfield, Suzanne¹⁰  Rosano, Caterina⁶ 

[1] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA USA

[2] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA

[3] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA

[4] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA

[5] Univ Calif San Francisco, San Francisco VA Med Ctr, San Francisco, CA 94143 USA

[6] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA

[7] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA

[8] Wake Forest Sch Med, Sticht Ctr Aging, Winston Salem, NC USA

[9] NIA, Lab Epidemiol & Populat Sci, Bethesda, MD 20892 USA

[10] Univ Tennessee, Ctr Hlth Sci, Dept Prevent Med, Memphis, TN 38163 USA

关键词: CRP;    Pro-inflammatory;    Diffusion tensor imaging;    Longitudinal;   

DOI  :  10.1016/j.neurobiolaging.2014.11.004

来源: Elsevier

【 摘 要 】

Protracted systemic inflammation has been associated with adverse effects on cognition and brain structure and may accelerate neurodegenerative disease processes; however, it is less clear whether changes in inflammation are associated with brain structure. We studied 276 black and white older adults (mean age = 83 years at time of imaging) enrolled in a prospective study of aging. Inflammation (measured with c-reactive protein, CRP) was assessed repeatedly over 6 years (i.e., year 2, 4, 6, and 8). Brain magnetic resonance imaging (MRIs) were obtained at years 10-11 with diffusion tensor imaging; regions of interest included late-myelinating areas vulnerable to aging, including frontal-parietal (superior longitudinal fasciculus [SLF]-dorsal) and temporal (SLF-temporal; uncinate) white matter tracts. Mean CRP values significantly declined (t = -5.54, p < 0.0001) over 6 years, and subject-specific slopes (best linear unbiased predictors of slopes) all showed a decline (mean = -0.57, standard deviation = 0.53) for our participant sample. More than 50% of study participants were still in the moderate to high cardiovascular risk range based on CRP values at year 8. After controlling for demographics, vascular risk factors and MRI white matter hyperintensities, larger decreases in CRP values over time were significantly associated with higher fractional anisotropy in the SLF-dorsal (beta = -0.0052, standard error [SE] = 0.003; 95% confidence interval [CI] = -0.0103 to -0.0025, p = 0.04), SLF-temporal (beta = -0.0109, SE = 0.004; 95% CI = -0.0189 to -0.0029, p = 0.008), and uncinate (beta = -0.0067, SE = 0.003; 95% CI = -0.0132 to -0.0001, p = 0.05) fasciculi. Results suggest that in a prospective cohort of older individuals, faster declines in inflammation over time are related to indicators of white matter health, even after accounting for vascular risk factors. (C) 2015 Elsevier Inc. All rights reserved.

【 授权许可】

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