Oxytocin alters patterns of brain activity and amygdalar connectivity by age during dynamic facial emotion identification

NEUROBIOLOGY OF AGING

卷:78

Article

Horta, Marilyn¹  Ziaei, Maryam²  Lin, Tian¹  Porges, Eric C.³  Fischer, Hakan⁴  Feifel, David⁵  Spreng, R. Nathan^6,7,8  Ebner, Natalie C.^1,3,9 

[1] Univ Florida, Dept Psychol, POB 112250, Gainesville, FL 32611 USA

[2] Univ Queensland, Ctr Adv Imaging, Brisbane, Qld, Australia

[3] Univ Florida, Dept Clin & Hlth Psychol, Ctr Cognit Aging & Memory, Gainesville, FL USA

[4] Stockholm Univ, Dept Psychol, Stockholm, Sweden

[5] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA

[6] McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ, Canada

[7] McGill Univ, Dept Psychol, Montreal, PQ, Canada

[8] McGill Univ, Dept Psychiat, Montreal, PQ, Canada

[9] Univ Florida, Inst Aging, Dept Aging & Geriatr Res, Gainesville, FL USA

关键词: Oxytocin;    Aging;    Emotion;    Amygdala;    Functional connectivity;   

DOI  :  10.1016/j.neurobiolaging.2019.01.016

来源: Elsevier

【 摘 要 】

Aging is associated with increased difficulty in facial emotion identification, possibly due to age-related network change. The neuropeptide oxytocin (OT) facilitates emotion identification, but this is understudied in aging. To determine the effects of OT on dynamic facial emotion identification across adulthood, 46 young and 48 older participants self-administered intranasal OT or a placebo in a randomized, double-blind procedure. Older participants were slower and less accurate in identifying emotions. Although there was no behavioral treatment effect, partial least squares analysis supported treatment effects on brain patterns during emotion identification that varied by age and emotion. For young participants, OT altered the processing of sadness and happiness, whereas for older participants, OT only affected the processing of sadness (15.3% covariance, p = 0.004). Furthermore, seed partial least squares analysis showed that older participants in the OT group recruited a large-scale amygdalar network that was positively correlated for anger, fear, and happiness, whereas older participants in the placebo group recruited a smaller, negatively correlated network (7% covariance, p = 0.002). Advancing the literature, these findings show that OT alters brain activity and amygdalar connectivity by age and emotion. (C) 2019 Elsevier Inc. All rights reserved.

【 授权许可】

Free