White matter in different regions evolves differently during progression to dementia

NEUROBIOLOGY OF AGING

卷:76

Article

Dadar, Mahsa^1,2  Maranzano, Josefina^2,4  Ducharme, Simon^2,3  Collins, D. Louis^1,2  Weiner, Michael W.^5,7  Aisen, Paul⁶  Weiner, Michael^7,90  Petersen, Ronald⁸  Jack, Clifford R., Jr.⁸  Jagust, William^5,9  Trojanowki, John Q.^10,35,91  Toga, Arthur W.^6,11  Beckett, Laurel¹²  Green, Robert C.^13,89  Saykin, Andrew J.¹⁴  Shaw, Leslie M.^10,35,91  Khachaturian, Zaven¹⁶  Sorensen, Greg¹⁷  Carrillo, Maria¹⁸  Kuller, Lew¹⁹  Paul, Steven²⁰  Davies, Peter²¹  Fillit, Howard²²  Hefti, Franz²³  Holtzman, David²⁴  Mesulam, M. Marcel²⁴  Potter, William²⁵  Snyder, Peter²⁶  Montine, Tom²⁷  Jimenez, Gustavo¹¹  Donohue, Michael^11,28  Gessert, Devon¹¹  Harless, Kelly¹¹  Salazar, Jennifer¹¹  Cabrera, Yuliana¹¹  Walter, Sarah¹¹  Hergesheimer, Lindsey¹¹  Harvey, Danielle¹²  Bernstein, Matthew⁸  Fox, Nick²⁹  Thompson, Paul³⁰  Schuff, Norbert³¹  DeCArli, Charles^12,71  Borowski, Bret⁸  Gunter, Jeff⁸  Senjem, Matt⁸  Vemuri, Prashanthi⁸  Jones, David⁸  Kantarci, Kejal⁸  Ward, Chad⁸  Koeppe, Robert A.³²  Foster, Norm³³  Reiman, Eric M.³⁴  Chen, Kewei³⁴  Mathis, Chet¹⁹  Landau, Susan^35,91  Lee, Virginia^35,91  Korecka, Magdalena^35,91  Figurski, Michal^35,91  Crawford, Karen¹¹  Neu, Scott¹¹  Foroud, Tatiana M.¹⁴  Potkin, Steven³⁶  Shen, Li¹⁴  Faber, Kelley¹⁴  Kim, Sungeun¹⁴  Nho, Kwangsik¹⁴  Thal, Lean²⁸  Thal, Leon²⁸  Buckholtz, Neil³⁷  Snyder, Peter J.²⁶  Albert, Marilyn^20,38  Frank, Richard³⁸  Hsiao, John³⁷  Quinn, Joseph³⁹  Silbert, Lisa C.³⁹  Lind, Betty³⁹  Kaye, Jeffrey A.³⁹  Carter, Raina³⁹  Dolen, Sara³⁹  Schneider, Lon S.⁶  Pawluczyk, Sonia⁶  Becerra, Mauricio⁶  Teodoro, Liberty⁶  Spann, Bryan M.⁶  Brewer, James⁴⁰  Vanderswag, Helen⁴⁰  Fleisher, Adam^34,40  Ziolkowski, Jaimie³²  Heidebrink, Judith L.³²  Lord, Joanne L.³²  Mason, Sara S.⁸  Albers, Colleen S.⁸  Knopman, David⁸  Johnson, Kris⁸  Villanueva-Meyer, Javier⁴¹  Pavlik, Valory⁴¹  Pacini, Nathaniel⁴¹  Lamb, Ashley⁴¹  Kass, Joseph S.⁴¹  Doody, Rachelle S.⁴¹  Shibley, Victoria⁴¹  Chowdhury, Munir⁴¹  Rountree, Susan^5,41  Dang, Mimi⁴¹  Stern, Yaakov⁴²  Honig, Lawrence S.⁴²  Bell, Karen L.⁴²  Yeh, Randy⁴²  Marson, Daniel⁴³  Geldmacher, David⁴³  Love, Marissa Natelson⁴³  Griffith, Randall⁴³  Clark, David⁴³  Brockington, John⁴³  Grossman, Hillel⁴⁴  Mitsis, Effie⁴⁴  Shah, Raj C.⁴⁵  Lamar, Melissa⁴⁵  Samuels, Patricia⁴⁵  Duara, Ranjan⁴⁶  Greig-Custo, Maria T.⁴⁶  Rodriguez, Rosemarie⁴⁶  Onyike, Chiadi³⁸  D'Agostino, Daniel, II³⁸  Kielb, Stephanie³⁸  Witbracht, Megan⁵¹  Sadowski, Martin⁴⁷  Sheikh, Mohammed O.⁴⁷  Singleton-Garvin, Jamika⁴⁷  Ulysse, Anaztasia⁴⁷  Gaikwad, Mrunalini⁴⁷  Doraiswamy, P. Murali⁴⁸  Petrella, Jeffrey R.⁴⁸  James, Olga⁴⁸  Borges-Neto, Salvador⁴⁸  Wong, Terence Z.⁴⁸  Coleman, Edward⁴⁸  Karlawish, Jason H.¹⁰  Wolk, David A.¹⁰  Vaishnavi, Sanjeev¹⁰  Clark, Christopher M.¹⁰  Arnold, Steven E.¹⁰  Smith, Charles D.⁴⁹  Jicha, Greg⁴⁹  Hardy, Peter⁴⁹  El Khouli, Riham⁴⁹  Oates, Elizabeth⁴⁹  Conrad, Gary⁴⁹  Lopez, Oscar L.¹⁹  Oakley, MaryAnn¹⁹  Simpson, Donna M.¹⁹  Porsteinsson, Anton P.⁵⁰  Martin, Kim⁵⁰  Kowalksi, Nancy⁵⁰  Keltz, Melanie⁵⁰  Goldstein, Bonnie S.⁵⁰  Makino, Kelly M.⁵⁰  Ismail, M. Saleem⁵⁰  Brand, Connie⁵⁰  Thai, Gaby⁵¹  Pierce, Aimee⁵¹  Yanez, Beatriz⁵¹  Sosa, Elizabeth⁵¹  Womack, Kyle⁵²  Mathews, Dana⁵²  Quiceno, Mary⁵²  Levey, Allan, I⁵³  Lah, James J.⁵³  Cellar, Janet S.⁵³  Burns, Jeffrey M.⁵⁴  Swerdlow, Russell H.⁵⁴  Brooks, William M.⁵⁴  Woo, Ellen⁵⁵  Silverman, Daniel H. S.⁵⁵  Teng, Edmond⁵⁵  Kremen, Sarah⁵⁵  Apostolova, Liana⁵⁵  Tingus, Kathleen⁵⁵  Lu, Po H.⁵⁵  Bartzokis, George⁵⁵  Graff-Radford, Neill R.⁵⁶  Parfitt, Francine⁵⁶  Poki-Walker, Kim⁵⁶  Farlow, Martin R.¹⁴  Hake, Ann Marie¹⁴  Matthews, Brandy R.¹⁴  Brosch, Jared R.¹⁴  Herring, Scott¹⁴  van Dyck, Christopher H.⁵⁷  Carson, Richard E.⁵⁷  Varma, Pradeep⁵⁷  Chertkow, Howard⁵⁸  Bergman, Howard⁵⁸  Hosein, Chris⁵⁸  Black, Sandra⁵⁹  Stefanovic, Bojana⁵⁹  Heyn, Chris (Chinthaka)⁵⁹  Hsiung, Ging-Yuek Robin⁶⁰  Mudge, Benita⁶⁰  Sossi, Vesna⁶⁰  Feldman, Howard⁶⁰  Assaly, Michele⁶⁰  Finger, Elizabeth^61,84  Pasternack, Stephen⁶¹  Pavlosky, William⁶¹  Rachinsky, Irina^61,84  Drost, Dick^61,84  Kertesz, Andrew^61,84  Bernick, Charles⁶²  Munic, Donna⁶²  Mesulam, Marek-Marsel²⁴  Rogalski, Emily²⁴  Lipowski, Kristine²⁴  Weintraub, Sandra²⁴  Bonakdarpour, Borna²⁴  Kerwin, Diana²⁴  Wu, Chuang-Kuo²⁴  Johnson, Nancy²⁴  Sadowsky, Carl⁶³  Villena, Teresa⁶³  Turner, Raymond Scott⁶⁴  Johnson, Kathleen⁶⁴  Reynolds, Brigid⁶⁴  Sperling, Reisa A.⁶⁵  Johnson, Keith A.⁶⁵  Marshall, Gad A.⁶⁵  Yesavage, Jerome⁶⁶  Taylor, Joy L.⁶⁶  Chao, Steven⁶⁶  Lane, Barton⁶⁶  Rosen, Allyson⁶⁶  Tinklenberg, Jared⁶⁶  Zamrini, Edward⁶⁷  Belden, Christine M.⁶⁷  Sirrel, Sherye A.⁶⁷  Kowall, Neil⁶⁸  Killiany, Ronald⁶⁸  Budson, Andrew E.⁶⁸  Norbash, Alexander⁶⁸  Johnson, Patricia Lynn⁶⁸  Obisesan, Thomas O.⁶⁹  Oyonumo, Ntekim E.⁶⁹  Allard, Joanne⁶⁹  Ogunlana, Olu⁶⁹  Lerner, Alan⁷⁰  Ogrocki, Paula⁷⁰  Tatsuoka, Curtis⁷⁰  Fatica, Parianne⁷⁰  Fletcher, Evan⁷¹  Maillard, Pauline⁷¹  Olichney, John⁷¹  Carmichael, Owen⁷¹  Kittur, Smita⁷²  Borrie, Michael⁷³  Lee, T-Y⁷³  Bartha, Rob⁷³  Johnson, Sterling⁷⁴  Asthana, Sanjay⁷⁴  Carlsson, Cynthia M.⁷⁴  Tariot, Pierre³⁴  Burke, Anna³⁴  Hetelle, Joel³⁴  DeMarco, Kathryn³⁴  Trncic, Nadira³⁴  Reeder, Stephanie³⁴  Bates, Vernice⁷⁵  Capote, Horacio⁷⁵  Rainka, Michelle⁷⁵  Scharre, Douglas W.⁷⁶  Kataki, Maria⁷⁶  Tarawneh, Rawan⁷⁶  Zimmerman, Earl A.⁷⁷  Celmins, Dzintra⁷⁷  Hart, David⁷⁷  Pearlson, Godfrey D.^77,78  Blank, Karen⁷⁸  Anderson, Karen⁷⁸  Flashman, Laura A.⁷⁹  Seltzer, Marc⁷⁹  Hynes, Mary L.⁷⁹  Santulli, Robert B.⁷⁹  Sink, Kaycee M.⁸⁰  Yang, Mia⁸⁰  Mintz, Akiva⁸⁰  Ott, Brian R.⁸¹  Tremont, Geoffrey⁸¹  Daiello, Lori A.⁸¹  Bodge, Courtney⁸²  Salloway, Stephen⁸²  Malloy, Paul⁸²  Correia, Stephen⁸²  Lee, Athena⁸²  Rosen, Howard J.^5,7  Miller, Bruce L.⁷  Perry, David^5,7  Mintzer, Jacobo⁸³  Spicer, Kenneth⁸³  Bachman, David⁸³  Pasternak, Stephen⁸⁴  Rogers, John⁸⁴  Pomara, Nunzio⁸⁵  Hernando, Raymundo⁸⁵  Sarrael, Antero⁸⁵  Miller, Delwyn D.⁸⁶  Smith, Karen Ekstam⁸⁶  Koleva, Hristina⁸⁶  Nam, Ki Won⁸⁶  Shim, Hyungsub⁸⁶  Schultz, Susan K.⁸⁶  Relkin, Norman²⁰  Chiang, Gloria²⁰  Lin, Michael²⁰  Ravdin, Lisa²⁰  Smith, Amanda⁸⁷  Leach, Christi⁸⁷  Raj, Balebail Ashok⁸⁷  Fargher, Kristin⁸⁷  Neylan, Thomas⁷  Grafman, Jordan⁸⁸  Friedl, Karl⁸⁸  Hayes, Jacqueline⁷  Finley, Shannon^7,15  Fleischman, Debra⁴⁵  Arfanakis, Konstantinos⁴⁵  Varon, Daniel⁴⁶  Greig, Maria T.⁴⁶  Goldstein, Bonnie⁵⁰  Martin, Kimberly S.⁵⁰  Potkin, Steven G.⁵¹  Preda, Adrian⁵¹  Nguyen, Dana⁵¹  Massoglia, Dino⁸³  Brawman-Mintzer, Olga⁸³  Martinez, Walter⁶³  Rosen, Howard^5,7  Behan, Kelly⁶⁴  Marshall, Gad⁶⁵  Sabbagh, Marwan N.⁶⁷  Jacobson, Sandra A.⁶⁷  Wolday, Saba⁶⁹  Johnson, Sterling C.⁷⁴  Fruehling, J. Jay⁷⁴  Harding, Sandra⁷⁴  Peskind, Elaine R.²⁷  Petrie, Eric C.²⁷  Li, Gail²⁷  Yesavage, Jerome A.⁶⁶  Furst, Ansgar J.⁶⁶  Mackin, Scott^5,7  Raman, Rema⁶  Drake, Erin⁸⁹  Donohue, Mike⁶  Shaffer, Elizabeth¹¹  Nelson, Craig^5,7  Bickford, David^5,7  Butters, Meryl¹⁹  Zmuda, Michelle¹⁹  Reyes, Denise⁸  Faber, Kelley M.¹⁴  Nudelman, Kelly N.¹⁴  Au, Yiu Ho⁵  Scherer, Kelly⁵  Catalinotto, Daniel⁵  Stark, Samuel⁵  Ong, Elise^5,7  Fernandez, Dariella^5,7 

[1] McGill Univ, NeuroImaging & Surg Tools Lab, Montreal Neurol Inst, Montreal, PQ, Canada

[2] McGill Univ, McConnell Brain Imaging Ctr, Montreal Neurol Inst, Montreal, PQ, Canada

[3] McGill Univ, Dept Psychiat, Hlth Ctr, Montreal, PQ, Canada

[4] Univ Quebec Trois Rivieres, Dept Anat, Trois Rivieres, PQ, Canada

[5] Univ Calif San Francisco, San Francisco, CA 94143 USA

[6] Univ Southern Calif, Los Angeles, CA USA

[7] UC San Francisco, San Francisco, CA USA

[8] Mayo Clin, Rochester, MN USA

[9] Univ Calif Berkeley, Berkeley, CA USA

[10] Univ Penn, Philadelphia, PA 19104 USA

[11] USC, Los Angeles, CA USA

[12] Univ Calif Davis, Davis, CA USA

[13] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA

[14] Indiana Univ, Bloomington, IN 47405 USA

[15] Washington Univ, St Louis, MO USA

[16] Prevent Alzheimers Dis 2020, Rockville, MD USA

[17] Siemens, Washington, DC USA

[18] Alzheimers Assoc, Chicago, IL USA

[19] Univ Pittsburgh, Pittsburgh, PA USA

[20] Cornell Univ, Ithaca, NY USA

[21] Yeshiva Univ, Albert Einstein Coll Med, New York, NY 10033 USA

[22] AD Drug Discovery Fdn, New York, NY USA

[23] Acumen Pharmaceut, Livermore, CA USA

[24] Northwestern Univ, Evanston, IL USA

[25] NIMH, Bethesda, MD 20892 USA

[26] Brown Univ, Providence, RI 02912 USA

[27] Univ Washington, Seattle, WA 98195 USA

[28] Univ Calif San Diego, San Diego, CA USA

[29] Univ London, London, England

[30] UCLA, Sch Med, Los Angeles, CA USA

[31] UCSF, MRI, San Francisco, CA USA

[32] Univ Michigan, Ann Arbor, MI 48109 USA

[33] Univ Utah, Salt Lake City, UT USA

[34] Banner Alzheimers Inst, Phoenix, AZ USA

[35] UPenn Sch Med, Philadelphia, PA USA

[36] UC Irvine, Irvine, CA USA

[37] NIA, Bethesda, MD 20892 USA

[38] Johns Hopkins Univ, Baltimore, MD USA

[39] Oregon Hlth & Sci Univ, Portland, OR 97201 USA

[40] Univ Calif San Diego, La Jolla, CA 92093 USA

[41] Baylor Coll Med, Houston, TX 77030 USA

[42] Columbia Univ, Med Ctr, New York, NY USA

[43] Univ Alabama Birmingham, Birmingham, AL USA

[44] Mt Sinai Sch Med, New York, NY USA

[45] Rush Univ, Med Ctr, Chicago, IL 60612 USA

[46] Wien Ctr, New York, NY USA

[47] NYU, New York, NY USA

[48] Duke Univ, Med Ctr, Durham, NC USA

[49] Univ Kentucky, Lexington, KY USA

[50] Univ Rochester, Med Ctr, Rochester, NY 14642 USA

[51] Univ Calif Irvine, IMIND, Irvine, CA USA

[52] Univ Texas Southwestern Med Sch, Dallas, TX USA

[53] Emory Univ, Atlanta, GA 30322 USA

[54] Univ Kansas, Med Ctr, Lawrence, KS 66045 USA

[55] Univ Calif Los Angeles, Los Angeles, CA USA

[56] Mayo Clin, Jacksonville, FL 32224 USA

[57] Yale Univ, Sch Med, New Haven, CT USA

[58] McGill Univ, Jewish Gen Hosp, Montreal, PQ, Canada

[59] Sunnybrook Hlth Sci, Toronto, ON, Canada

[60] UBC Clin AD & Related Disorders, Vancouver, BC, Canada

[61] Cognit Neurolo St Josephs, St Josephs, ON, Canada

[62] Cleveland Clin, Lou Ruvo Ctr Brain Hlth, Cleveland, OH 44106 USA

[63] Premiere Res Inst, Palm Beach Neurol, W Palm Beach, FL USA

[64] Georgetown Univ, Med Ctr, Washington, DC 20007 USA

[65] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA

[66] Stanford Univ, Stanford, CA 94305 USA

[67] Banner Sun Hlth Res Inst, Sun City, AZ USA

[68] Boston Univ, Boston, MA 02215 USA

[69] Howard Univ, Washington, DC 20059 USA

[70] Case Western Reserve Univ, Cleveland, OH 44106 USA

[71] Univ Calif Davis, Sacramento, CA 95817 USA

[72] Neurol Care CNY, Syracuse, NY USA

[73] Parkwood Inst, London, ON, Canada

[74] Univ Wisconsin, Madison, WI USA

[75] Dent Neurol Inst, Buffalo, NY USA

[76] Ohio State Univ, Columbus, OH 43210 USA

[77] Albany Med Coll, Albany, NY 12208 USA

[78] Hartford Hosp, Olin Neuropsychiat Res Ctr, Hartford, CT 06115 USA

[79] Dartmouth Hitchcock Med Ctr, Lebanon, NH 03766 USA

[80] Wake Forest Univ, Hlth Sci, Winston Salem, NC 27109 USA

[81] Rhode Isl Hosp, Providence, RI USA

[82] Butler Hosp, Providence, RI 02906 USA

[83] Med Univ South Carolina, Columbia, SC USA

[84] St Josephs Hlth Ctr, Toronto, ON, Canada

[85] Nathan S Kline Inst Psychiat Res, Orangeburg, NY USA

[86] Univ Iowa, Coll Med, Iowa City, IA USA

[87] Univ S Florida, USF Hlth Byrd Alzheimers Inst, Tampa, FL USA

[88] Northwestern Univ, Feinberg Sch Med, Rehabil Inst Chicago, Evanston, IL USA

[89] HMS, BWH, Boston, MA USA

[90] Core PI, San Francisco, CA USA

[91] UPenn, Perelman Sch Med, Philadelphia, PA USA

关键词: Small vessel disease;    White matter hyperintensities;    Dementia;    Alzheimer's disease;    Mild cognitive impairment;   

DOI  :  10.1016/j.neurobiolaging.2018.12.004

来源: Elsevier

【 摘 要 】

White matter hyperintensities (WMHs) are common in individuals with mild cognitive impairment(MCI) and Alzheimer's disease. Patients with MCI with high WMH volumes are known to have an increased chance of conversion to Alzheimer's disease compared with those without WMHs. In this article, we assess the differences between patients with MCI that remain stable (N = 413) and those that progress to dementia (N = 178) in terms of WMH volume (as a surrogate of amount of tissue damage) and T1-weighted (T1w) image hypointensity (as a surrogate of severity of tissue damage) in periventricular, deep, and juxtacortical brain regions. Together, lesion volume and T1w hypointensity are used as a surrogate of vascular disease burden. Our results show a significantly greater increase of all regional WMH volumes in the MCI population that converts to dementia (p < 0.001). T1w hypointensity for the juxtacortical WMHs was significantly lower in the converter group (p < 0.0001) and was not affected by age. Conversely, T1w hypointensity in other regions showed a significant decrease with age (p < 0.0001). Within the converters, Time2Conversion was associated with both WMH volume and T1w hypointensity (p < 0.0001), and conversion to dementia was significantly associated with decreased intensity (and not volume) of periventricular and juxtacortical WMHs (p < 0.001). These changes differ according to the WM region, suggesting that different mechanisms affect the juxtacortical area in comparison to deep and periventricular regions in the process of conversion to dementia. (C) 2018 Elsevier Inc. All rights reserved.

【 授权许可】

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