White matter integrity is associated with cerebrospinal fluid markers of Alzheimer's disease in normal adults

NEUROBIOLOGY OF AGING

卷:35

Article

Gold, Brian T.^1,2,3  Zhu, Zude¹  Brown, Christopher A.¹  Andersen, Anders H.^1,2  Ladu, Mary Jo⁴  Tai, Leon⁴  Jicha, Greg A.^3,5  Kryscio, Richard J.^3,6  Estus, Steven^3,7  Nelson, Peter T.^3,8  Scheff, Steve W.^1,3  Abner, Erin^3,9  Schmitt, Frederick A.^3,5  Van Eldik, Linda J.^1,3  Smith, Charles D.^2,5 

[1] Univ Kentucky, Coll Med, Dept Anat & Neurobiol, Lexington, KY 40536 USA

[2] Univ Kentucky, Magnet Resonance Imaging Spectroscopy Ctr, Lexington, KY 40536 USA

[3] Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USA

[4] Univ Illinois, Dept Anat & Cell Biol, Chicago, IL USA

[5] Univ Kentucky, Dept Neurol, Lexington, KY 40536 USA

[6] Univ Kentucky, Dept Stat, Lexington, KY 40536 USA

[7] Univ Kentucky, Dept Physiol, Lexington, KY 40536 USA

[8] Univ Kentucky, Dept Pathol, Lexington, KY 40536 USA

[9] Univ Kentucky, Dept Epidemiol, Lexington, KY 40536 USA

关键词: Normal older adults;    CSF;    White matter;    DTI;    Preclinical AD;   

DOI  :  10.1016/j.neurobiolaging.2014.04.030

来源: Elsevier

【 摘 要 】

We explored whether white matter (WM) integrity in cognitively normal (CN) older adults is associated with cerebrospinal fluid (CSF) markers of Alzheimer's disease pathology. Twenty CN older adults underwent lumbar puncture and magnetic resonance imaging within a few days of each other. Analysis of diffusion tensor imaging data involved a priori region of interest and voxelwise approaches. The region of interest results revealed a positive correlation between CSF measures of amyloid-beta (A beta(42) and A beta(42)/p-Tau(181)) and WM integrity in the fornix, a relationship which persisted after controlling for hippocampal volume and fornix volume. Lower WM integrity in the same portion of the fornix was also associated with reduced performance on the Digit Symbol test. Subsequent exploratory voxelwise analyses indicated a positive correlation between CSF A beta(42)/p-Tau(181) and WM integrity in bilateral portions of the fornix, superior longitudinal fasciculus, inferior fronto-occipital fasciculus, and in the corpus callosum and left inferior longitudinal fasciculus. Our results link lower WM microstructural integrity in CN older adults with CSF biomarkers of Alzheimer's disease and suggest that this association in the fornix may be independent of volumetric measures. (C) 2014 Elsevier Inc. All rights reserved.

【 授权许可】

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