3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects

NEUROBIOLOGY OF AGING

卷:31

Article

Apostolova, Liana G.^1,2  Hwang, Kristy S.²  Andrawis, John P.³  Green, Amity E.⁴  Babakchanian, Sona²  Morra, Jonathan H.²  Toga, Arthur W.²  Trojanowski, John Q.⁵  Shaw, Leslie M.⁵  Jack, Clifford R., Jr.⁶  Petersen, Ronald C.⁷  Aisen, Paul S.⁸  Jagust, William J.^9,10  Koeppe, Robert A.¹¹  Mathis, Chester A.¹²  Weiner, Michael W.^13,14  Thompson, Paul M.² 

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Mary S Easton Ctr Alzheimers Dis Res, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Lab Neuro Imaging, Los Angeles, CA 90095 USA

[3] Univ Chicago, Pritzker Sch Med, Chicago, IL 60637 USA

[4] Monash Univ, Clayton, Vic 3800, Australia

[5] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[6] Mayo Clin, Dept Diagnost Radiol, Rochester, MN USA

[7] Mayo Clin, Dept Neurol, Rochester, MN USA

[8] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA

[9] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA

[10] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA

[11] Univ Michigan, Dept Radiol, Div Nucl Med, Ann Arbor, MI 48109 USA

[12] Univ Pittsburgh, Dept Radiol, Pittsburgh, PA 15260 USA

[13] Dept Vet Affairs Med Ctr, San Francisco, CA USA

[14] Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA

关键词: Alzheimer's disease;    MRI;    Magnetic resonance imaging;    Imaging;    PIB;    Amyloid imaging;    Abeta;    tau;    Hippocampus;    Atrophy;    Biomarkers;    ADNI;   

DOI  :  10.1016/j.neurobiolaging.2010.05.003

来源: Elsevier

【 摘 要 】

Cerebrospinal fluid (CSF) measures of Ab and tau, Pittsburgh Compound B (PIB) imaging and hippocampal atrophy are promising Alzheimer's disease biomarkers yet the associations between them are not known. We applied a validated, automated hippocampal labeling method and 3D radial distance mapping to the 1.5T structural magnetic resonance imaging (MRI) data of 388 ADNI subjects with baseline CSF Ab(42), total tau (t-tau) and phosphorylated tau (p-tau(181)) and 98 subjects with positron emission tomography (PET) imaging using PIB. We used linear regression to investigate associations between hippocampal atrophy and average cortical, parietal and precuneal PIB standardized uptake value ratio (SUVR) and CSF Ab(42), t-tau, p-tau(181), t-tau/Ab(42) and p-tau(181)/Ab(42). All CSF measures showed significant associations with hippocampal volume and radial distance in the pooled sample. Strongest correlations were seen for p-tau(181), followed by p-tau(181)/Ab(42) ratio, t-tau/Ab(42) ratio, t-tau and Ab(42). p-tau(181) showed stronger correlation in ApoE4 carriers, while t-tau showed stronger correlation in ApoE4 noncarriers. Of the 3 PIB measures the precuneal SUVR showed strongest associations with hippocampal atrophy. (C) 2010 Published by Elsevier Inc.

【 授权许可】

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