Distant histories of mild traumatic brain injury exacerbate age-related differences in white matter properties

NEUROBIOLOGY OF AGING

卷:107

Article

Vakhtin, Andrei A.¹  Zhang, Yu²  Wintermark, Max³  Ashford, John W.^2,4  Furst, Ansgar J.^2,4,5,6 

[1] Lovelace Biomed & Environm Res Inst, Mind Res Network, Albuquerque, NM USA

[2] Palo Alto Vet Affairs Hosp, War Related Illness & Injury Study Ctr WRIISC, Palo Alto, CA USA

[3] Stanford Univ, Neuroradiol, Sch Med, Stanford, CA USA

[4] Stanford Univ, Sch Med, Psychiat & Behav Sci, Stanford, CA USA

[5] Stanford Univ, Neurol & Neurol Sci, Sch Med, Stanford, CA USA

[6] Palo Alto Vet Affairs Hosp, Polytrauma Syst Care, Palo Alto, CA USA

关键词: Mild Traumatic Brain Injury (mTBI);    Aging;    White Matter;    Diffusion Tensor Imaging (DTI);    Tractography;   

DOI  :  10.1016/j.neurobiolaging.2021.07.002

来源: Elsevier

【 摘 要 】

We examined associations of distant histories of mild traumatic brain injury (mTBI) with non-linear and linear trajectories of white matter (WM) properties across a wide age range (23-77). Diffusion tensor imaging (DTI) data obtained from 171 Veterans with histories of clinically diagnosed mTBIs and 115 controls were subjected to tractography, isolating 20 major WM tracts. Non-linear and linear effects of age on each tract's diffusion properties were examined in terms of their interactions with group (mTBI and control). The non-linear model revealed 7 tracts in which the mTBI group's DTI metrics rapidly deviated from control trajectories in middle and late adulthoods, despite the injuries having occurred in the late 20s, on average. In contrast, no interactions between prior injuries and age were detected when examining linear trajectories. Distant mTBIs may thus accelerate normal age-related trajectories of WM degeneration much later in life. As such, life-long histories of head trauma should be assessed in all patients in their mid-to-late adulthoods, whether neurologically healthy or presenting with seemingly unrelated neuropathology. (c) 2021 Elsevier Inc. All rights reserved.

【 授权许可】

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