Epigenetic mechanisms in Alzheimer's disease

NEUROBIOLOGY OF AGING

卷:32

Review

Mastroeni, Diego¹  Grover, Andrew¹  Delvaux, Elaine¹  Whiteside, Charisse¹  Coleman, Paul D.¹  Rogers, Joseph¹ 

[1] Banner Sun Hlth Res Inst, Sun City, AZ 85372 USA

关键词: Epigenetics;    DNA methylation;    Histone acetylation;    rDNA;    miRNA;    Genetics;    Gene expression;    Amyloid beta peptide;    Inflammation;    Oxidative stress;    Cell cycle;   

DOI  :  10.1016/j.neurobiolaging.2010.08.017

来源: Elsevier

【 摘 要 】

Epigenetic modifications help orchestrate sweeping developmental, aging, and disease-causing changes in phenotype by altering transcriptional activity in multiple genes spanning multiple biologic pathways. Although previous epigenetic research has focused primarily on dividing cells, particularly in cancer, recent studies have shown rapid, dynamic, and persistent epigenetic modifications in neurons that have significant neuroendocrine, neurophysiologic, and neurodegenerative consequences. Here, we provide a review of the major mechanisms for epigenetic modification and how they are reportedly altered in aging and Alzheimer's disease (AD). Because of their reach across the genome, epigenetic mechanisms may provide a unique integrative framework for the pathologic diversity and complexity of AD. (C) 2011 Elsevier Inc. All rights reserved.

【 授权许可】

Free