Brain structural differences between 73-and 92-year olds matched for childhood intelligence, social background, and intracranial volume

NEUROBIOLOGY OF AGING

卷:62

Article

Ritchie, Stuart J.^1,2  Dickie, David Alexander^3,4,5,6  Cox, Simon R.^1,2  Hernandez, Maria del C. Valdes^2,4,5,6  Sibbett, Ruth^2,7  Pattie, Alison¹  Anblagan, Devasuda^2,5,6  Redmond, Paul¹  Royle, Natalie A.^2,4,5,6  Corley, Janie^1,2  Maniega, Susana Munoz^2,4,5,6  Taylor, Adele M.¹  Karama, Sherif^8,9  Booth, Tom^1,2  Gow, Alan J.^2,10  Starr, John M.^2,7  Bastin, Mark E.^2,4,5,6  Wardlaw, Joanna M.^2,4,5,6  Deary, Ian J.^1,2 

[1] Univ Edinburgh, Dept Psychol, Edinburgh, Midlothian, Scotland

[2] Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, 7 George Sq, Edinburgh EH8 9JZ, Midlothian, Scotland

[3] Univ Glasgow, Coll Med Vet & Life Sci, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland

[4] Univ Edinburgh, Brain Res Imaging Ctr, Edinburgh, Midlothian, Scotland

[5] Scottish Imaging Network, Edinburgh, Midlothian, Scotland

[6] Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland

[7] Univ Edinburgh, Alzheimer Scotland Dementia Res Ctr, Edinburgh, Midlothian, Scotland

[8] McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Dept Neurol & Neurosurg, Montreal, PQ, Canada

[9] McGill Univ, Douglas Mental Hlth Univ Inst, Dept Psychiat, Verdun, PQ, Canada

[10] Heriot Watt Univ, Dept Psychol, Edinburgh, Midlothian, Scotland

关键词: Aging;    Structural MRI;    Brain volume;    White matter hyperintensities;    Lesion mapping;   

DOI  :  10.1016/j.neurobiolaging.2017.10.005

来源: Elsevier

【 摘 要 】

Fully characterizing age differences in the brain is a key task for combating aging-related cognitive decline. Using propensity score matching on 2 independent, narrow-age cohorts, we used data on childhood cognitive ability, socioeconomic background, and intracranial volume to match participants at mean age of 92 years (n = 42) to very similar participants at mean age of 73 years (n = 126). Examining a variety of global and regional structural neuroimaging variables, there were large differences in gray and white matter volumes, cortical surface area, cortical thickness, and white matter hyperintensity volume and spatial extent. In a mediation analysis, the total volume of white matter hyperintensities and total cortical surface area jointly mediated 24.9% of the relation between age and general cognitive ability (tissue volumes and cortical thickness were not significant mediators in this analysis). These findings provide an unusual and valuable perspective on neurostructural aging, in which brains from the 8th and 10th decades of life differ widely despite the same cognitive, socioeconomic, and brain-volumetric starting points. (C) 2017 The Authors. Published by Elsevier Inc.

【 授权许可】

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