Innovative approaches in cognitive aging

NEUROBIOLOGY OF AGING

卷:83

Article; Proceedings Paper

Austad, Steven N.¹  Wood, Marcelo A.²  Villeda, Saul A.³  Voss, Joel L.⁴  Sahay, Amar⁵  Albert, Marilyn⁶ 

[1] Univ Alabama Birmingham, Dept Biol, Birmingham, AL 35294 USA

[2] Univ Calif Irvine, Sch Biol Sci, Dept Neurobiol & Behav, Irvine, CA 92717 USA

[3] Univ Calif San Francisco, Sch Med, Dept Anat, San Francisco, CA USA

[4] Northwestern Univ, Dept Med Social Sci, Ken & Ruth Davee Dept Neurol, Dept Psychiat & Behav Sci,Feinberg Sch Med, Chicago, IL 60611 USA

[5] Harvard Med Sch, Massachusetts Gen Hosp, Broad Inst MIT & Harvard, Harvard Stem Cell Inst,Ctr Regenerat Med,Dept Psy, Boston, MA 02115 USA

[6] Johns Hopkins Sch Med, Dept Neurol, Baltimore, MD 21205 USA

关键词: Reserve;    Resilience;    Novel approaches;    Epigenetics;    Regeneration;    Intervention;   

DOI  :  10.1016/j.neurobiolaging.2019.04.013

来源: Elsevier

【 摘 要 】

Novel approaches to address cognitive aging and to delay or prevent cognitive decline in older individuals will require a better understanding of the biological and environmental factors that contribute to it. Studies in animal models-in particular, animals whose cognitive trajectory across their life span closely tracks that of humans-can provide important insights into the factors that contribute to the accumulation of reserve and ways in which it is preserved or depleted. A better understanding of the molecular processes that underlie these elements would enhance and guide not only research but also treatment approaches to these issues. These treatment approaches may include noninvasive brain stimulation and drug treatments to promote youthfulness or combat the aging process. It is important to realize, however, that these processes occur in the context of the human experience, and studies of them must consider the complexity and individuality of each person's life. (C) 2019 Published by Elsevier Inc.

【 授权许可】

Free