Age differences in hippocampal activation during gist-based false recognition

NEUROBIOLOGY OF AGING

卷:46

Article

Paige, Laura E.¹  Cassidy, Brittany S.^1,2  Schacter, Daniel L.³  Gutchess, Angela H.¹ 

[1] Brandeis Univ, Dept Psychol, 415 South St,MS 062, Waltham, MA 02453 USA

[2] Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN USA

[3] Harvard Univ, Dept Psychol, William James Hall, 33 Kirkland St, Cambridge, MA 02138 USA

关键词: Gist;    False memory;    Aging;    Memory;    fMRI;    Hippocampus;   

DOI  :  10.1016/j.neurobiolaging.2016.06.014

来源: Elsevier

【 摘 要 】

Age-related increases in reliance on gist-based processes can cause increased false recognition. Understanding the neural basis for this increase helps to elucidate a mechanism underlying this vulnerability in memory. We assessed age differences in gist-based false memory by increasing image set size at encoding, thereby increasing the rate of false alarms. False alarms during a recognition test elicited increased hippocampal activity for older adults as compared to younger adults for the small set sizes, whereas the age groups had similar hippocampal activation for items associated with larger set sizes. Interestingly, younger adults had stronger connectivity between the hippocampus and posterior temporal regions relative to older adults during false alarms for items associated with large versus small set sizes. With increased gist, younger adults might rely more on additional processes (e.g., semantic associations) during recognition than older adults. Parametric modulation revealed that younger adults had increased anterior cingulate activity than older adults with decreasing set size, perhaps indicating difficulty in using monitoring processes in error-prone situations. (C) 2016 Elsevier Inc. All rights reserved.

【 授权许可】

Free