Variations in the APOE allele or BDNF Val66Met polymorphism are not associated with changes in cognitive function following a tertiary education intervention in older adults: the Tasmanian Healthy Brain Project

NEUROBIOLOGY OF AGING

卷:55

Article

Thow, Megan E.^1,2  Summers, Mathew J.^2,3  Summers, Jeffery J.^1,4  Saunders, Nichole L.²  Vickers, James C.² 

[1] Univ Tasmania, Sch Med, Hobart, Tas, Australia

[2] Univ Tasmania, Fac Hlth, Wicking Dementia Res & Educ Ctr, Hobart, Tas, Australia

[3] Univ Sunshine Coast, Thompson Inst, Sunshine Coast Mind & Neurosci, Birtinya, Qld, Australia

[4] Liverpool John Moores Univ, Res Inst Sport & Exercise Sci, Liverpool, Merseyside, England

关键词: Apolipoprotein;    APOE;    BDNF;    Cognition;    Education;    Episodic memory;    Executive function;    Language;    Older adults;    Working memory;   

DOI  :  10.1016/j.neurobiolaging.2017.03.028

来源: Elsevier

【 摘 要 】

The apolipoprotein (APOE) epsilon 4 allele and the Met variant of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism are associated with reduced cognitive function in older adults. The aim of this study was to examine the independent and interactional effect of the APOE epsilon 4 allele and BDNF Val66Met polymorphism on cognitive function in a cohort of healthy older adults who had undertaken further university level education. Multiple group latent growth curve modeling revealed no change in cognitive function over time in APOE epsilon 4-carriers or in BDNF Met-carriers, nor in carriers of both APOE-epsilon 4 and BDNF-Met alleles. Further, the results indicate that allelic variation in either APOE or BDNF does not modify the beneficial effects of a university-based education intervention on cognitive function over a 4-year period following the intervention. (C) 2017 Elsevier Inc. All rights reserved.

【 授权许可】

Free